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10.1038/s41598-018-23062-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-23062-6 C5869738!5869738!29588511     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29588511|t=2018. Structure and Distribution of an Unrecognized Interstitium in Human Tissues |pdf=|usr=}}{{29588511}} gab.com Text Structure and Distribution of an Unrecognized Interstitium in Human Tissues JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29588511 #FOAvip Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60?70??m during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles. These bundles are intermittently lined on one side by fibroblast-like cells that stain with endothelial markers and vimentin, although there is a highly unusual and extensive unlined interface between the matrix proteins of the bundles and the surrounding fluid. We observed similar structures in numerous tissues that are subject to intermittent or rhythmic compression, including the submucosae of the entire gastrointestinal tract and urinary bladder, the dermis, the peri-bronchial and peri-arterial soft tissues, and fascia. These anatomic structures may be important in cancer metastasis, edema, fibrosis, and mechanical functioning of many or all tissues and organs. In sum, we describe the anatomy and histology of a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues, a novel expansion and specification of the concept of the human interstitium. Twit Text FOAVip Structure and Distribution of an Unrecognized Interstitium in Human Tissues ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29588511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29588511 #FOAvip English Wikipedia <ref>{{Cite pmid|29588511}}</ref> Structure and Distribution of an Unrecognized Interstitium in Human Tissues #MMPMID29588511 Benias PC; Wells RG; Sackey-Aboagye B; Klavan H; Reidy J; Buonocore D; Miranda M; Kornacki S; Wayne M; Carr-Locke DL; Theise ND Sci Rep 2018[]; 8 (ä): ä PMID29588511show ga Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60?70??m during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles. These bundles are intermittently lined on one side by fibroblast-like cells that stain with endothelial markers and vimentin, although there is a highly unusual and extensive unlined interface between the matrix proteins of the bundles and the surrounding fluid. We observed similar structures in numerous tissues that are subject to intermittent or rhythmic compression, including the submucosae of the entire gastrointestinal tract and urinary bladder, the dermis, the peri-bronchial and peri-arterial soft tissues, and fascia. These anatomic structures may be important in cancer metastasis, edema, fibrosis, and mechanical functioning of many or all tissues and organs. In sum, we describe the anatomy and histology of a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues, a novel expansion and specification of the concept of the human interstitium. äStructure and Distribution of an Unrecognized Interstitium in Human Ti(epmc).pdf DeepDyve Pubget Overpricing