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10.1038/s41467-018-02977-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-02977-8 C5869589!5869589!29588478     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29588478|t=2018. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans |pdf=|usr=}}{{29588478}} gab.com Text Ikaros family zinc finger 1 regulates dendritic cell development and function in humans JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29588478 #FOAvip Ikaros family zinc finger 1 (IKZF1) is a haematopoietic transcription factor required for mammalian B-cell development. IKZF1 deficiency also reduces plasmacytoid dendritic cell (pDC) numbers in mice, but its effects on human DC development are unknown. Here we show that heterozygous mutation of IKZF1 in human decreases pDC numbers and expands conventional DC1 (cDC1). Lenalidomide, a drug that induces proteosomal degradation of IKZF1, also decreases pDC numbers in vivo, and reduces the ratio of pDC/cDC1 differentiated from progenitor cells in vitro in a dose-dependent manner. In addition, non-classical monocytes are reduced by IKZF1 deficiency in vivo. DC and monocytes from patients with IKZF1 deficiency or lenalidomide-treated cultures secrete less IFN-?, TNF and IL-12. These results indicate that human DC development and function are regulated by IKZF1, providing further insights into the consequences of IKZF1 mutation on immune function and the mechanism of immunomodulation by lenalidomide. Twit Text FOAVip Ikaros family zinc finger 1 regulates dendritic cell development and function in humans ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29588478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29588478 #FOAvip English Wikipedia <ref>{{Cite pmid|29588478}}</ref> Ikaros family zinc finger 1 regulates dendritic cell development and function in humans #MMPMID29588478 Cytlak U; Resteu A; Bogaert D; Kuehn HS; Altmann T; Gennery A; Jackson G; Kumanovics A; Voelkerding KV; Prader S; Dullaers M; Reichenbach J; Hill H; Haerynck F; Rosenzweig SD; Collin M; Bigley V Nat Commun 2018[]; 9 (ä): ä PMID29588478show ga Ikaros family zinc finger 1 (IKZF1) is a haematopoietic transcription factor required for mammalian B-cell development. IKZF1 deficiency also reduces plasmacytoid dendritic cell (pDC) numbers in mice, but its effects on human DC development are unknown. Here we show that heterozygous mutation of IKZF1 in human decreases pDC numbers and expands conventional DC1 (cDC1). Lenalidomide, a drug that induces proteosomal degradation of IKZF1, also decreases pDC numbers in vivo, and reduces the ratio of pDC/cDC1 differentiated from progenitor cells in vitro in a dose-dependent manner. In addition, non-classical monocytes are reduced by IKZF1 deficiency in vivo. DC and monocytes from patients with IKZF1 deficiency or lenalidomide-treated cultures secrete less IFN-?, TNF and IL-12. These results indicate that human DC development and function are regulated by IKZF1, providing further insights into the consequences of IKZF1 mutation on immune function and the mechanism of immunomodulation by lenalidomide. äIkaros family zinc finger 1 regulates dendritic cell development and f(epmc).pdf DeepDyve Pubget Overpricing