Enterovirus Transmission by Secretory Autophagy #MMPMID29558400
Mutsafi Y; Altan-Bonnet N
Viruses 2018[Mar]; 10 (3): ä PMID29558400show ga
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.