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10.3389/fimmu.2018.00393 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00393 C5869260!5869260 !29616016     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29616016 &cmd=llinks): Failed to open stream: HTTP request failed! 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Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning |pdf=|usr=}}{{29616016 }} gab.com Text Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29616016 #FOAvip Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the underling causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of danger/damage-associated molecular patterns liberated from endothelial-bound proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We hypothesized that HS induces apoptosis or necroptosis in murine cardiomyocytes. By using a novel Medical-In silico approach that combines conventional cell culture experiments with machine learning algorithms, we aimed to reduce a significant part of the expensive and time-consuming cell culture experiments and data generation by using computational intelligence (refinement and replacement). Cardiomyocytes exposed to HS showed an activation of the intrinsic apoptosis signal pathway via cytochrome C and the activation of caspase 3 (both p?<?0.001). Notably, the exposure of HS resulted in the induction of necroptosis by tumor necrosis factor ? and receptor interaction protein 3 (p?<?0.05; p?<?0.01) and, hence, an increased level of necrotic cardiomyocytes. In conclusion, using this novel Medical-In silico approach, our data suggest (i) that HS induces necroptosis in cardiomyocytes by phosphorylation (activation) of receptor-interacting protein 3, (ii) that HS is a therapeutic target in trauma- or sepsis-associated cardiomyopathy, and (iii) indicate that this proof-of-concept is a first step toward simulating the extent of activated components in the pro-apoptotic pathway induced by HS with only a small data set gained from the in vitro experiments by using machine learning algorithms. Twit Text FOAVip Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29616016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29616016 #FOAvip English Wikipedia <ref>{{Cite pmid|29616016 }}</ref> Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning #MMPMID29616016 Zechendorf E ; Vaßen P ; Zhang J ; Hallawa A ; Martincuks A ; Krenkel O ; Müller-Newen G ; Schuerholz T ; Simon TP ; Marx G ; Ascheid G ; Schmeink A ; Dartmann G ; Thiemermann C ; Martin L Front Immunol 2018[]; 9 (ä): 393 PMID29616016 show ga Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the underling causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of danger/damage-associated molecular patterns liberated from endothelial-bound proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We hypothesized that HS induces apoptosis or necroptosis in murine cardiomyocytes. By using a novel Medical-In silico approach that combines conventional cell culture experiments with machine learning algorithms, we aimed to reduce a significant part of the expensive and time-consuming cell culture experiments and data generation by using computational intelligence (refinement and replacement). Cardiomyocytes exposed to HS showed an activation of the intrinsic apoptosis signal pathway via cytochrome C and the activation of caspase 3 (both p? |*Machine Learning [MESH] |Algorithms [MESH] |Animals [MESH] |Apoptosis [MESH] |Cardiomyopathies/*metabolism/pathology [MESH] |Caspase 3/metabolism [MESH] |Cell Culture Techniques/*methods [MESH] |Cells, Cultured [MESH] |Cytochromes c/metabolism [MESH] |Heparitin Sulfate/*metabolism [MESH] |Humans [MESH] |Mice [MESH] |Myocytes, Cardiac/*physiology [MESH] |Necrosis [MESH] |Receptor-Interacting Protein Serine-Threonine Kinases/metabolism [MESH] |Sepsis/*metabolism/pathology [MESH] |Signal Transduction [MESH]Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medica(epmc).pdf DeepDyve Pubget Overpricing