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10.1111/tra.12552 http://scihub22266oqcxt.onion/10.1111/tra.12552 C5869154!5869154 !29437282     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29437282 &cmd=llinks): Failed to open stream: HTTP request failed! 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Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages |pdf=|usr=}}{{29437282 }} gab.com Text Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages JO: Traffic http://www.kidney.de/pget.php?&tw=1&pmid=29437282 #FOAvip Despite the rapidly expanding use of antibody-based therapeutics to treat cancer, knowledge of the cellular processes following phagocytosis of antibody-opsonized tumor cells is limited. Here we report the formation of a phagosome-associated vacuole that is observed in macrophages as these degradative compartments mature following phagocytosis of HER2-positive cancer cells in the presence of the HER2-specific antibody, trastuzumab. We demonstrate that this vacuole is a distinct organelle that is closely apposed to the phagosome. Furthermore, the size of the phagosome-associated vacuole is increased by inhibition of the mTOR pathway. Collectively, the identification of this vacuolar compartment has implications for understanding the subcellular trafficking processes leading to the destruction of phagocytosed, antibody-opsonized cancer cells by macrophages. Twit Text FOAVip Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages ????Traffic http://www.kidney.de/pget.php?&tw=1&pmid=29437282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29437282 #FOAvip English Wikipedia <ref>{{Cite pmid|29437282 }}</ref> Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages #MMPMID29437282 Velmurugan R ; Ramakrishnan S ; Kim M ; Ober RJ ; Ward ES Traffic 2018[Apr]; 19 (4 ): 273-284 PMID29437282 show ga Despite the rapidly expanding use of antibody-based therapeutics to treat cancer, knowledge of the cellular processes following phagocytosis of antibody-opsonized tumor cells is limited. Here we report the formation of a phagosome-associated vacuole that is observed in macrophages as these degradative compartments mature following phagocytosis of HER2-positive cancer cells in the presence of the HER2-specific antibody, trastuzumab. We demonstrate that this vacuole is a distinct organelle that is closely apposed to the phagosome. Furthermore, the size of the phagosome-associated vacuole is increased by inhibition of the mTOR pathway. Collectively, the identification of this vacuolar compartment has implications for understanding the subcellular trafficking processes leading to the destruction of phagocytosed, antibody-opsonized cancer cells by macrophages. |Animals [MESH] |Antibodies/immunology [MESH] |Humans [MESH] |Lysosomes/metabolism [MESH] |Macrophages/*metabolism [MESH] |Membrane Fusion/physiology [MESH] |Mice [MESH] |Neoplasms/immunology/metabolism [MESH] |Phagocytosis/*immunology/physiology [MESH] |Phagosomes/*metabolism [MESH] |Receptors, IgG/metabolism [MESH]Phagocytosis of antibody-opsonized tumor cells leads to the formation (epmc).pdf DeepDyve Pubget Overpricing