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Phagocytosis of antibody-opsonized tumor cells leads to the formation of a
discrete vacuolar compartment in macrophages
#MMPMID29437282
Velmurugan R
; Ramakrishnan S
; Kim M
; Ober RJ
; Ward ES
Traffic
2018[Apr]; 19
(4
): 273-284
PMID29437282
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Despite the rapidly expanding use of antibody-based therapeutics to treat cancer,
knowledge of the cellular processes following phagocytosis of antibody-opsonized
tumor cells is limited. Here we report the formation of a phagosome-associated
vacuole that is observed in macrophages as these degradative compartments mature
following phagocytosis of HER2-positive cancer cells in the presence of the
HER2-specific antibody, trastuzumab. We demonstrate that this vacuole is a
distinct organelle that is closely apposed to the phagosome. Furthermore, the
size of the phagosome-associated vacuole is increased by inhibition of the mTOR
pathway. Collectively, the identification of this vacuolar compartment has
implications for understanding the subcellular trafficking processes leading to
the destruction of phagocytosed, antibody-opsonized cancer cells by macrophages.
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