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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP
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MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer #MMPMID29616037
Wu J; Ding J; Yang J; Guo X; Zheng Y
Front Immunol 2018[]; 9 (ä): ä PMID29616037show ga
Nuclear factor kappa B (NF-?B) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression. NF-?B expression is transient and tightly regulated in normal cells, but it is activated in cancer cells. Recently, numerous studies have demonstrated microRNAs (miRNAs) play a vital role in the NF-?B signaling pathway and NF-?B-associated immune responses, radioresistance and drug resistance of cancer, some acting as inhibitors and the others as activators. Although it is still in infancy, targeting NF-?B or the NF-?B signaling pathway by miRNAs is becoming a promising strategy of cancer treatment.