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10.3389/fimmu.2018.00546

http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00546
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C5868594!5868594!29616037
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suck abstract from ncbi


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pmid29616037      Front+Immunol 2018 ; 9 (ä): ä
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  • MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer #MMPMID29616037
  • Wu J; Ding J; Yang J; Guo X; Zheng Y
  • Front Immunol 2018[]; 9 (ä): ä PMID29616037show ga
  • Nuclear factor kappa B (NF-?B) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression. NF-?B expression is transient and tightly regulated in normal cells, but it is activated in cancer cells. Recently, numerous studies have demonstrated microRNAs (miRNAs) play a vital role in the NF-?B signaling pathway and NF-?B-associated immune responses, radioresistance and drug resistance of cancer, some acting as inhibitors and the others as activators. Although it is still in infancy, targeting NF-?B or the NF-?B signaling pathway by miRNAs is becoming a promising strategy of cancer treatment.
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