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2018 ; 2018
(ä): 8726046
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Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic
Review and Meta-Analysis of Fifteen Clinical Trials
#MMPMID29721018
Liu W
; Yang X
; Huang J
Int J Endocrinol
2018[]; 2018
(ä): 8726046
PMID29721018
show ga
AIMS: Insulin degludec (IDeg) and insulin glargine (IGlar) are both proved to be
effective in diabetes. This study aimed to assess the effects and safety of IDeg
versus IGlar. METHODS: A systematic literature search was conducted using the
PubMed, EMBASE, and Cochrane Library electronic databases to identify all
randomized controlled trials (RCTs). RESULTS: Fifteen RCTs were identified. The
combined data showed that the decrease in the glycosylated hemoglobin (HbA1c)
level was slightly different, and the proportion of patients who achieved
HbA1c?7% was similar between the IDeg and IGlar groups. Further, a
statistically significant decrease in the fasting plasma glucose level was
observed in the IDeg group as compared to the IGlar group. In patients with T2DM,
IDeg was associated with lower rates of overall hypoglycemia. Nocturnal
hypoglycemia was significantly lower in the case of IDeg than in the case of
IGlar in both T1DM and T2DM patients. No statistically significant differences
were observed between the groups. CONCLUSIONS: Compared with IGlar, IDeg is
associated with equivalent glycemic control and a statistically significantly
lower rate of nocturnal hypoglycemia in patients with T1DM and T2DM. In T2DM
patients, IDeg also provides better results in terms of overall hypoglycemia.