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10.1136/annrheumdis-2017-212268 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2017-212268 C5867400!5867400 !29275334     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29275334 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Rheum+Dis 2018 ; 77 (3 ): 412-416 Nephropedia Template TP {{tp|p=29275334 |t=2018. Effect of rituximab on a salivary gland ultrasound score in primary Sjögren s syndrome: results of the TRACTISS randomised double-blind multicentre substudy |pdf=|usr=}}{{29275334 }} gab.com Text Effect of rituximab on a salivary gland ultrasound score in primary Sjögren s syndrome: results of the TRACTISS randomised double-blind multicentre substudy JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=29275334 #FOAvip OBJECTIVES: To compare the effects of rituximab versus placebo on salivary gland ultrasound (SGUS) in primary Sjögren's syndrome (PSS) in a multicentre, multiobserver phase III trial substudy. METHODS: Subjects consenting to SGUS were randomised to rituximab or placebo given at weeks 0, 2, 24 and 26, and scanned at baseline and weeks 16 and 48. Sonographers completed a 0-11 total ultrasound score (TUS) comprising domains of echogenicity, homogeneity, glandular definition, glands involved and hypoechoic foci size. Baseline-adjusted TUS values were analysed over time, modelling change from baseline at each time point. For each TUS domain, we fitted a repeated-measures logistic regression model to model the odds of a response in the rituximab arm (?1-point improvement) as a function of the baseline score, age category, disease duration and time point. RESULTS: 52 patients (n=26?rituximab and n=26?placebo) from nine centres completed baseline and one or more follow-up visits. Estimated between-group differences (rituximab-placebo) in baseline-adjusted TUS were -1.2 (95% CI -2.1 to -0.3; P=0.0099) and -1.2 (95% CI -2.0 to -0.5; P=0.0023) at weeks 16 and 48. Glandular definition improved in the rituximab arm with an OR of 6.8 (95% CI 1.1 to 43.0; P=0.043) at week 16 and 10.3 (95% CI 1.0 to 105.9; P=0.050) at week 48. CONCLUSIONS: We demonstrated statistically significant improvement in TUS after rituximab compared with placebo. This encourages further research into both B cell depletion therapies in PSS and SGUS as an imaging biomarker. TRIAL REGISTRATION NUMBER: 65360827, 2010-021430-64; Results. Twit Text FOAVip Effect of rituximab on a salivary gland ultrasound score in primary Sjögren s syndrome: results of the TRACTISS randomised double-blind multicentre substudy ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=29275334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29275334 #FOAvip English Wikipedia <ref>{{Cite pmid|29275334 }}</ref> Effect of rituximab on a salivary gland ultrasound score in primary Sjögren s syndrome: results of the TRACTISS randomised double-blind multicentre substudy #MMPMID29275334 Fisher BA ; Everett CC ; Rout J ; O'Dwyer JL ; Emery P ; Pitzalis C ; Ng WF ; Carr A ; Pease CT ; Price EJ ; Sutcliffe N ; Makdissi J ; Tappuni AR ; Gendi NST ; Hall FC ; Ruddock SP ; Fernandez C ; Hulme CT ; Davies KA ; Edwards CJ ; Lanyon PC ; Moots RJ ; Roussou E ; Richards A ; Sharples LD ; Bombardieri M ; Bowman SJ Ann Rheum Dis 2018[Mar]; 77 (3 ): 412-416 PMID29275334 show ga OBJECTIVES: To compare the effects of rituximab versus placebo on salivary gland ultrasound (SGUS) in primary Sjögren's syndrome (PSS) in a multicentre, multiobserver phase III trial substudy. METHODS: Subjects consenting to SGUS were randomised to rituximab or placebo given at weeks 0, 2, 24 and 26, and scanned at baseline and weeks 16 and 48. Sonographers completed a 0-11 total ultrasound score (TUS) comprising domains of echogenicity, homogeneity, glandular definition, glands involved and hypoechoic foci size. Baseline-adjusted TUS values were analysed over time, modelling change from baseline at each time point. For each TUS domain, we fitted a repeated-measures logistic regression model to model the odds of a response in the rituximab arm (?1-point improvement) as a function of the baseline score, age category, disease duration and time point. RESULTS: 52 patients (n=26?rituximab and n=26?placebo) from nine centres completed baseline and one or more follow-up visits. Estimated between-group differences (rituximab-placebo) in baseline-adjusted TUS were -1.2 (95% CI -2.1 to -0.3; P=0.0099) and -1.2 (95% CI -2.0 to -0.5; P=0.0023) at weeks 16 and 48. Glandular definition improved in the rituximab arm with an OR of 6.8 (95% CI 1.1 to 43.0; P=0.043) at week 16 and 10.3 (95% CI 1.0 to 105.9; P=0.050) at week 48. CONCLUSIONS: We demonstrated statistically significant improvement in TUS after rituximab compared with placebo. This encourages further research into both B cell depletion therapies in PSS and SGUS as an imaging biomarker. TRIAL REGISTRATION NUMBER: 65360827, 2010-021430-64; Results. |Adult [MESH] |Aged [MESH] |Double-Blind Method [MESH] |Female [MESH] |Humans [MESH] |Immunologic Factors/*therapeutic use [MESH] |Male [MESH] |Middle Aged [MESH] |Rituximab/*therapeutic use [MESH] |Salivary Glands/diagnostic imaging/*drug effects [MESH] |Sjogren's Syndrome/diagnostic imaging/*drug therapy [MESH] |Treatment Outcome [MESH]Effect of rituximab on a salivary gland ultrasound score in primary Sj(epmc).pdf DeepDyve Pubget Overpricing