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10.3389/fnagi.2018.00066 http://scihub22266oqcxt.onion/10.3389/fnagi.2018.00066 C5867310!5867310!29615891     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Aging+Neurosci 2018 ; 10 (ä): ä Nephropedia Template TP {{tp|p=29615891|t=2018. Catalpol Inhibits Amyloid-? Generation Through Promoting ?-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells |pdf=|usr=}}{{29615891}} gab.com Text Catalpol Inhibits Amyloid- Generation Through Promoting -Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells JO: Front Aging Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29615891 #FOAvip Amyloid-? (A?) peptides play a crucial role in the pathogenesis of Alzheimer?s disease (AD), due to its neurotoxicity. Thus, blocking A? generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia glutinosa, has shown neuroprotective activities through inhibiting soluble A? production, degrading A? peptide, and attenuating A? toxicity and neuroinflammatory responses. In the present study, we aimed to evaluate whether catalpol reduce A? generation associated with regulating amyloid precursor protein (APP) proteolytic processing. By using Swedish mutant APP overexpressed N2a (SweAPP N2a) cells treated with catalpol, we found that catalpol was not able to reduce the expression levels of ?-secretase (BACE-1) and ?-secretase (PS1, APH-1, PEN-2 and Nicastrin). By contrast, catalpol had a significant promotion effect on the expression of ?-secretase (ADAM10) and its proteolytic products, sAPP? and C83, suggesting that catalpol reduced the production of A? might be involved in non-amyloidogenic APP pathway. In addition, we confirmed that the extracellular signal-related kinase/cAMP-response element binding protein (ERK/CREB) signaling pathways were responsible for the up-regulation of ADAM10 in catalpol-treated SweAPP N2a cells. The present data, for the first time, have demonstrated that the effect of catalpol on the inhibiting A? generation might be closely related to ?-cleavage of APP processing. Twit Text FOAVip Catalpol Inhibits Amyloid- Generation Through Promoting -Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells ????Front Aging Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29615891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29615891 #FOAvip English Wikipedia <ref>{{Cite pmid|29615891}}</ref> Catalpol Inhibits Amyloid-? Generation Through Promoting ?-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells #MMPMID29615891 Wang Z; Huang X; Zhao P; Zhao L; Wang ZY Front Aging Neurosci 2018[]; 10 (ä): ä PMID29615891show ga Amyloid-? (A?) peptides play a crucial role in the pathogenesis of Alzheimer?s disease (AD), due to its neurotoxicity. Thus, blocking A? generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia glutinosa, has shown neuroprotective activities through inhibiting soluble A? production, degrading A? peptide, and attenuating A? toxicity and neuroinflammatory responses. In the present study, we aimed to evaluate whether catalpol reduce A? generation associated with regulating amyloid precursor protein (APP) proteolytic processing. By using Swedish mutant APP overexpressed N2a (SweAPP N2a) cells treated with catalpol, we found that catalpol was not able to reduce the expression levels of ?-secretase (BACE-1) and ?-secretase (PS1, APH-1, PEN-2 and Nicastrin). By contrast, catalpol had a significant promotion effect on the expression of ?-secretase (ADAM10) and its proteolytic products, sAPP? and C83, suggesting that catalpol reduced the production of A? might be involved in non-amyloidogenic APP pathway. In addition, we confirmed that the extracellular signal-related kinase/cAMP-response element binding protein (ERK/CREB) signaling pathways were responsible for the up-regulation of ADAM10 in catalpol-treated SweAPP N2a cells. The present data, for the first time, have demonstrated that the effect of catalpol on the inhibiting A? generation might be closely related to ?-cleavage of APP processing. äCatalpol Inhibits Amyloid-? Generation Through Promoting ?-Cleavage of(epmc).pdf DeepDyve Pubget Overpricing