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10.1002/advs.201700666 http://scihub22266oqcxt.onion/10.1002/advs.201700666 C5867037!5867037!29593968     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2018 ; 5 (3): ä Nephropedia Template TP {{tp|p=29593968|t=2018. Engineering a Tumor Microenvironment?Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells |pdf=|usr=}}{{29593968}} gab.com Text Engineering a Tumor Microenvironment Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=29593968 #FOAvip The insufficient number of cells suitable for transplantation is a long?standing problem to cell?based therapies aimed at tissue regeneration. Xenogeneic cancer cells (XCC) may be an alternative source of therapeutic cells, but their transplantation risks both immune rejection and unwanted spreading. In this study, a strategy to facilitate XCC transplantation is reported and their spreading in vivo is confined by constructing an engineering matrix that mimics the characteristics of tumor microenvironment. The data show that this matrix, a tumor homogenate?containing hydrogel (THAG), successfully creates an immunosuppressive enclave after transplantation into immunocompetent mice. XCC of different species and tissue origins seeded into THAG survive well, integrated with the host and developed the intrinsic morphology of the native tissue, without being eliminated or spreading out of the enclave. Most strikingly, immortalized human hepatocyte cells and rat ??cells loaded into THAG exert the physiological functions of the human liver and rat pancreas islets, respectively, in the mouse body. This study demonstrates a novel and feasible approach to harness the unique features of tumor development for tissue transplantation and regenerative medicine. Twit Text FOAVip Engineering a Tumor Microenvironment Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=29593968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29593968 #FOAvip English Wikipedia <ref>{{Cite pmid|29593968}}</ref> Engineering a Tumor Microenvironment?Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells #MMPMID29593968 Wang Z; Wang C; Abudukeremu A; Rui X; Liu S; Zhang X; Zhang M; Zhang J; Dong L Adv Sci (Weinh) 2018[Mar]; 5 (3): ä PMID29593968show ga The insufficient number of cells suitable for transplantation is a long?standing problem to cell?based therapies aimed at tissue regeneration. Xenogeneic cancer cells (XCC) may be an alternative source of therapeutic cells, but their transplantation risks both immune rejection and unwanted spreading. In this study, a strategy to facilitate XCC transplantation is reported and their spreading in vivo is confined by constructing an engineering matrix that mimics the characteristics of tumor microenvironment. The data show that this matrix, a tumor homogenate?containing hydrogel (THAG), successfully creates an immunosuppressive enclave after transplantation into immunocompetent mice. XCC of different species and tissue origins seeded into THAG survive well, integrated with the host and developed the intrinsic morphology of the native tissue, without being eliminated or spreading out of the enclave. Most strikingly, immortalized human hepatocyte cells and rat ??cells loaded into THAG exert the physiological functions of the human liver and rat pancreas islets, respectively, in the mouse body. This study demonstrates a novel and feasible approach to harness the unique features of tumor development for tissue transplantation and regenerative medicine. äEngineering a Tumor Microenvironment?Mimetic Niche for Tissue Regenera(epmc).pdf DeepDyve Pubget Overpricing