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10.1155/2018/2784701 http://scihub22266oqcxt.onion/10.1155/2018/2784701 C5866902!5866902 !29713239     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29713239 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2018 ; 2018 (ä): 2784701 Nephropedia Template TP {{tp|p=29713239 |t=2018. Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals |pdf=|usr=}}{{29713239 }} gab.com Text Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29713239 #FOAvip OBJECTIVE: Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5?,6?-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-?, CRP). MATERIAL AND METHODS: The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5?,6?-epoxycholesterol, and unoxidized cholesterol (ECh). Serum concentrations of studied parameters were determined at 45-day intervals. The study was continued for six months. RESULTS: We demonstrated that adding 5?,6?-epoxycholesterol to basic fodder significantly affected lipid status of the experimental animals, increasing total cholesterol and LDL cholesterol levels, as well as HCY and ADMA levels, whilst leaving the PON-1 activity unaffected. Additionally, the ECh group presented with significantly higher concentrations of inflammatory biomarkers (IL-6, TNF-?, and CRP). In the Ch group, lower yet significant (as compared to the C group) changes of levels of studied parameters were observed. CONCLUSION: Exposure of animals with experimentally induced hypercholesterolemia to 5?,6?-epoxycholesterol increases dyslipidaemia, endothelial dysfunction, and inflammatory response. Twit Text FOAVip Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29713239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29713239 #FOAvip English Wikipedia <ref>{{Cite pmid|29713239 }}</ref> Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals #MMPMID29713239 Wielkoszy?ski T ; Zalejska-Fiolka J ; Strzelczyk JK ; Owczarek AJ ; Cholewka A ; Furma?ski M ; Stanek A Mediators Inflamm 2018[]; 2018 (ä): 2784701 PMID29713239 show ga OBJECTIVE: Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5?,6?-epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF-?, CRP). MATERIAL AND METHODS: The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5?,6?-epoxycholesterol, and unoxidized cholesterol (ECh). Serum concentrations of studied parameters were determined at 45-day intervals. The study was continued for six months. RESULTS: We demonstrated that adding 5?,6?-epoxycholesterol to basic fodder significantly affected lipid status of the experimental animals, increasing total cholesterol and LDL cholesterol levels, as well as HCY and ADMA levels, whilst leaving the PON-1 activity unaffected. Additionally, the ECh group presented with significantly higher concentrations of inflammatory biomarkers (IL-6, TNF-?, and CRP). In the Ch group, lower yet significant (as compared to the C group) changes of levels of studied parameters were observed. CONCLUSION: Exposure of animals with experimentally induced hypercholesterolemia to 5?,6?-epoxycholesterol increases dyslipidaemia, endothelial dysfunction, and inflammatory response. |Animals [MESH] |Arginine/analogs & derivatives/blood [MESH] |Aryldialkylphosphatase/blood [MESH] |C-Reactive Protein/metabolism [MESH] |Cholesterol/blood/pharmacology [MESH] |Dyslipidemias/blood [MESH] |Homocysteine/metabolism [MESH] |Hypercholesterolemia/*blood/chemically induced [MESH] |Inflammation/*blood/chemically induced [MESH] |Interleukin-6/blood [MESH] |Lipids/blood [MESH] |Male [MESH] |Oxysterols/*adverse effects [MESH] |Rabbits [MESH]Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Acce(epmc).pdf DeepDyve Pubget Overpricing