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10.1073/pnas.1711335115 http://scihub22266oqcxt.onion/10.1073/pnas.1711335115 C5866538!5866538!29507226     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (12): 3120-5 Nephropedia Template TP {{tp|p=29507226|t=2018. Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells |pdf=|usr=}}{{29507226}} gab.com Text Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29507226 #FOAvip Many patients with B cell lymphoma carry alterations in the gene coding for the transcription factor Foxp1. High Foxp1 expression has been linked to poor prognosis in those malignancies; however, the physiological functions of Foxp1 in mature B cells remain unknown. By employing genetic mouse models, we show that Foxp1 deletion results in reduced B cell numbers and impaired antibody production upon T cell-independent immunization. Foxp1-deficient mature B cells are impaired in survival and exhibit an increased proliferation capacity, and transcriptional analysis identified defective expression of the prosurvival Bcl-xl gene. Our results provide insight into the regulation of mature B cell survival by Foxp1 and have implications for understanding the role of Foxp1 in the development of B cell malignancies. Twit Text FOAVip Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29507226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29507226 #FOAvip English Wikipedia <ref>{{Cite pmid|29507226}}</ref> Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells #MMPMID29507226 Patzelt T; Keppler SJ; Gorka O; Thoene S; Wartewig T; Reth M; Förster I; Lang R; Buchner M; Ruland J Proc Natl Acad Sci U S A 2018[Mar]; 115 (12): 3120-5 PMID29507226show ga Many patients with B cell lymphoma carry alterations in the gene coding for the transcription factor Foxp1. High Foxp1 expression has been linked to poor prognosis in those malignancies; however, the physiological functions of Foxp1 in mature B cells remain unknown. By employing genetic mouse models, we show that Foxp1 deletion results in reduced B cell numbers and impaired antibody production upon T cell-independent immunization. Foxp1-deficient mature B cells are impaired in survival and exhibit an increased proliferation capacity, and transcriptional analysis identified defective expression of the prosurvival Bcl-xl gene. Our results provide insight into the regulation of mature B cell survival by Foxp1 and have implications for understanding the role of Foxp1 in the development of B cell malignancies. äFoxp1 controls mature B cell survival and the development of follicula(epmc).pdf DeepDyve Pubget Overpricing