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10.1152/physrev.00008.2017 http://scihub22266oqcxt.onion/10.1152/physrev.00008.2017 C5866358!5866358!29212789     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2018 ; 98 (1): 117-214 Nephropedia Template TP {{tp|p=29212789|t=2018. Pancreatic ?-Cell Electrical Activity and Insulin Secretion: Of Mice and Men |pdf=|usr=}}{{29212789}} gab.com Text Pancreatic -Cell Electrical Activity and Insulin Secretion: Of Mice and Men JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=29212789 #FOAvip The pancreatic ?-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration. Impaired insulin secretion results in the chronic hyperglycemia that characterizes type 2 diabetes (T2DM), which currently afflicts >450 million people worldwide. The healthy ?-cell acts as a glucose sensor matching its output to the circulating glucose concentration. It does so via metabolically induced changes in electrical activity, which culminate in an increase in the cytoplasmic Ca2+ concentration and initiation of Ca2+-dependent exocytosis of insulin-containing secretory granules. Here, we review recent advances in our understanding of the ?-cell transcriptome, electrical activity, and insulin exocytosis. We highlight salient differences between mouse and human ?-cells, provide models of how the different ion channels contribute to their electrical activity and insulin secretion, and conclude by discussing how these processes become perturbed in T2DM. Twit Text FOAVip Pancreatic -Cell Electrical Activity and Insulin Secretion: Of Mice and Men ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=29212789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29212789 #FOAvip English Wikipedia <ref>{{Cite pmid|29212789}}</ref> Pancreatic ?-Cell Electrical Activity and Insulin Secretion: Of Mice and Men #MMPMID29212789 Rorsman P; Ashcroft FM Physiol Rev 2018[Jan]; 98 (1): 117-214 PMID29212789show ga The pancreatic ?-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration. Impaired insulin secretion results in the chronic hyperglycemia that characterizes type 2 diabetes (T2DM), which currently afflicts >450 million people worldwide. The healthy ?-cell acts as a glucose sensor matching its output to the circulating glucose concentration. It does so via metabolically induced changes in electrical activity, which culminate in an increase in the cytoplasmic Ca2+ concentration and initiation of Ca2+-dependent exocytosis of insulin-containing secretory granules. Here, we review recent advances in our understanding of the ?-cell transcriptome, electrical activity, and insulin exocytosis. We highlight salient differences between mouse and human ?-cells, provide models of how the different ion channels contribute to their electrical activity and insulin secretion, and conclude by discussing how these processes become perturbed in T2DM. äPancreatic ?-Cell Electrical Activity and Insulin Secretion: Of Mice a(epmc).pdf DeepDyve Pubget Overpricing