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10.1007/s12668-018-0513-8

http://scihub22266oqcxt.onion/10.1007/s12668-018-0513-8
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suck abstract from ncbi

pmid29600159
      Bionanoscience 2018 ; 8 (1 ): 484-489
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  • Immunosuppressant Peptide Abu-TGIRIS-Abu-NH(2) and its Application for Treatment of Multiple Sclerosis #MMPMID29600159
  • Turobov VI ; Azev VN ; Shevelev AB ; Pozdniakova NV ; Biryukova YK ; Murashev AN ; Lipkin VM ; Udovichenko IP
  • Bionanoscience 2018[]; 8 (1 ): 484-489 PMID29600159 show ga
  • Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11-20 of human Ig heavy chain (conserved motif of V(H) domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~?10(-9) M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lymphocytes, exhibits ACTH-like neurotropic activity and was suggested as a potential drug for treatment of a multiple sclerosis (MS). Here, we report a sequence and method of synthesis of Abu-TGIRIS-Abu-NH(2) (Abu, alpha-aminobutyric acid), an artificial analogue of immunocortin. Biological trials of peritoneally injected Abu-TGIRIS-Abu-NH(2) gave an evidence of its better efficacy versus immunocortin in a test for suppression of the experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats.
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