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10.3892/mmr.2018.8501 http://scihub22266oqcxt.onion/10.3892/mmr.2018.8501 C5865976!5865976 !29393388     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29393388 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2018 ; 17 (4 ): 5116-5124 Nephropedia Template TP {{tp|p=29393388 |t=2018. Hypoxia?induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast?like synoviocytes in rheumatoid arthritis |pdf=|usr=}}{{29393388 }} gab.com Text Hypoxia induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast like synoviocytes in rheumatoid arthritis JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29393388 #FOAvip Impaired apoptosis of rheumatoid arthritis (RA)?fibroblast?like synoviocytes (FLS) is pivotal in the process of RA. Peptidyl arginine deiminase type IV (PADI4) is associated with autoantibody regulation via histone citrullination in RA. The present study aimed to investigate the role of PADI4 in the apoptosis of RA?FLS. FLS were isolated from patients with RA and a rat model. The effects of PADI4 on RA?FLS were investigated in vitro and in vivo. Hypoxia?induced autophagy was induced by 1% O2 and was detected by immunohistochemical and immunofluorescence analysis; in addition, apoptosis was detected by flow cytometry. RA?FLS obtained from RA rat model exhibited significant proliferation under severe hypoxia conditions. Hypoxia also significantly induced autophagy and elevated the expression of PADI4. Subsequently, short hairpin RNA?mediated PADI4 knockdown was demonstrated to significantly inhibit hypoxia?induced autophagy and promote apoptosis in RA?FLS. The results of these in vitro and in vivo studies suggested that PADI4 may be closely associated with hypoxia?induced autophagy, and the inhibition of hypoxia?induced autophagy by PADI4 knockdown may contribute to an increase in the apoptosis of RA?FLS. Twit Text FOAVip Hypoxia induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast like synoviocytes in rheumatoid arthritis ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=29393388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29393388 #FOAvip English Wikipedia <ref>{{Cite pmid|29393388 }}</ref> Hypoxia?induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast?like synoviocytes in rheumatoid arthritis #MMPMID29393388 Fan T ; Zhang C ; Zong M ; Fan L Mol Med Rep 2018[Apr]; 17 (4 ): 5116-5124 PMID29393388 show ga Impaired apoptosis of rheumatoid arthritis (RA)?fibroblast?like synoviocytes (FLS) is pivotal in the process of RA. Peptidyl arginine deiminase type IV (PADI4) is associated with autoantibody regulation via histone citrullination in RA. The present study aimed to investigate the role of PADI4 in the apoptosis of RA?FLS. FLS were isolated from patients with RA and a rat model. The effects of PADI4 on RA?FLS were investigated in vitro and in vivo. Hypoxia?induced autophagy was induced by 1% O2 and was detected by immunohistochemical and immunofluorescence analysis; in addition, apoptosis was detected by flow cytometry. RA?FLS obtained from RA rat model exhibited significant proliferation under severe hypoxia conditions. Hypoxia also significantly induced autophagy and elevated the expression of PADI4. Subsequently, short hairpin RNA?mediated PADI4 knockdown was demonstrated to significantly inhibit hypoxia?induced autophagy and promote apoptosis in RA?FLS. The results of these in vitro and in vivo studies suggested that PADI4 may be closely associated with hypoxia?induced autophagy, and the inhibition of hypoxia?induced autophagy by PADI4 knockdown may contribute to an increase in the apoptosis of RA?FLS. |*Autophagy [MESH] |Aged [MESH] |Animals [MESH] |Apoptosis/*genetics [MESH] |Arthritis, Rheumatoid/*genetics/*metabolism/pathology [MESH] |Cell Proliferation/genetics [MESH] |Cell Survival/genetics [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Hypoxia/*genetics/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Protein-Arginine Deiminase Type 4 [MESH] |Protein-Arginine Deiminases/*genetics [MESH] |Rats [MESH]Hypoxia?induced autophagy is inhibited by PADI4 knockdown, which promo(epmc).pdf DeepDyve Pubget Overpricing