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2017 ; 16
(5
): 6736-6742
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Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with
collagen?induced arthritis
#MMPMID28901438
Wang F
; Wan J
; Li Q
; Zhang M
; Wan Q
; Ji C
; Li H
; Liu R
; Han M
Mol Med Rep
2017[Nov]; 16
(5
): 6736-6742
PMID28901438
show ga
Lysyl oxidase (LOX) serves an important role in remodeling the extracellular
matrix and angiogenesis in various types of cancer; however, whether LOX is
involved in the pathogenesis of rheumatoid arthritis remains unknown. In order to
investigate this in the present study, ??aminopropionitrile, an inhibitor of LOX,
was injected intraperitoneally into rats with type II collagen?induced arthritis
(CIA). Subsequently, synovial hyperplasia was examined by hematoxyl in and eosin
staining, and the microvascular density (MVD) and expression levels of LOX,
matrix metalloproteinase (MMP)?2 and MMP?9 in the synovial membrane and fluid
were determined by immunohistochemistry and ELISA, respectively. The enzyme
activity of LOX was evaluated by the Amplex Red Hydrogen Peroxide method. The
results demonstrated an increased amount of rough synovial membranes, higher MVD
in these membranes and more synovial cell layers in CIA rats compared with in the
control rats. In addition, higher enzymatic activity of LOX and higher expression
levels of MMP?2 and MMP?9 were revealed in CIA rats compared with in the control
rats. Notably, ??aminopropionitrile inhibited paw swelling and the decreased the
arthritis index, the MVD in the synovial membranes and the expression levels of
MMP?2 and MMP?9. Furthermore, the expression level of LOX in the synovial
membranes was positively associated with the MVD and the expression levels of
MMP?2 and MMP?9, suggesting that LOX promotes synovial hyperplasia and
angiogenesis and that LOX may be a potential therapeutic target for rheumatoid
arthritis.
|Aminopropionitrile/pharmacology/therapeutic use
[MESH]
free
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