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10.2147/OTT.S159894

http://scihub22266oqcxt.onion/10.2147/OTT.S159894
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C5865567!5865567!29593421
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suck abstract from ncbi


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pmid29593421      Onco+Targets+Ther 2018 ; 11 (ä): 1553-61
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  • Forecast of actin-binding proteins as the oncotarget in osteosarcoma ? a review of mechanism, diagnosis and therapy #MMPMID29593421
  • Fu Y; Yu W; Cai H; Lu A
  • Onco Targets Ther 2018[]; 11 (ä): 1553-61 PMID29593421show ga
  • Osteosarcoma (OS) is the most common bone malignant tumor with a high rate of lung metastasis and principally emerges in children and adolescents. Although neoadjuvant chemotherapy is widely used around the world, a high rate of chemoresistance occurs and frequently generates a poor prognosis. Therefore, finding a new appropriate prognostic marker for OS is a valuable research direction, which will give patients a better chance to receive proper therapy. Actin-binding proteins (ABPs) are a group of proteins that interact with actin cytoskeleton and play a crucial role in the regulation of the cell motility and morphology in eukaryotes. Meanwhile, ABPs also act as a bridge between the cytomembrane and nucleus, which transmit the outside-in and inside-out signals in cytoplasm. Furthermore, ABPs alter the dynamic structure of actin and regulate the invasion and metastasis of cancer. Hence, ABPs have a wide application in predicting the prognosis, and may be new targets, in tumor therapy. This review focuses on a series of ABPs and discusses their modulatory functions. It provides a new insight into the classification of ABPs? functions in the process of invasion and metastasis in OS and illuminates the potential ability in predicting the prognosis of OS patients.
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