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Forecast of actin-binding proteins as the oncotarget in osteosarcoma - a review
of mechanism, diagnosis and therapy
#MMPMID29593421
Fu Y
; Yu W
; Cai H
; Lu A
Onco Targets Ther
2018[]; 11
(?): 1553-1561
PMID29593421
show ga
Osteosarcoma (OS) is the most common bone malignant tumor with a high rate of
lung metastasis and principally emerges in children and adolescents. Although
neoadjuvant chemotherapy is widely used around the world, a high rate of
chemoresistance occurs and frequently generates a poor prognosis. Therefore,
finding a new appropriate prognostic marker for OS is a valuable research
direction, which will give patients a better chance to receive proper therapy.
Actin-binding proteins (ABPs) are a group of proteins that interact with actin
cytoskeleton and play a crucial role in the regulation of the cell motility and
morphology in eukaryotes. Meanwhile, ABPs also act as a bridge between the
cytomembrane and nucleus, which transmit the outside-in and inside-out signals in
cytoplasm. Furthermore, ABPs alter the dynamic structure of actin and regulate
the invasion and metastasis of cancer. Hence, ABPs have a wide application in
predicting the prognosis, and may be new targets, in tumor therapy. This review
focuses on a series of ABPs and discusses their modulatory functions. It provides
a new insight into the classification of ABPs' functions in the process of
invasion and metastasis in OS and illuminates the potential ability in predicting
the prognosis of OS patients.
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