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10.1038/s41387-017-0002-0 http://scihub22266oqcxt.onion/10.1038/s41387-017-0002-0 C5865549!5865549!29259155     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutr+Diabetes 2017 ; 7 (12): ä Nephropedia Template TP {{tp|p=29259155|t=2017. Central IGF1 improves glucose tolerance and insulin sensitivity in mice |pdf=|usr=}}{{29259155}} gab.com Text Central IGF1 improves glucose tolerance and insulin sensitivity in mice JO: Nutr Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=29259155 #FOAvip Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions. Twit Text FOAVip Central IGF1 improves glucose tolerance and insulin sensitivity in mice ????Nutr Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=29259155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29259155 #FOAvip English Wikipedia <ref>{{Cite pmid|29259155}}</ref> Central IGF1 improves glucose tolerance and insulin sensitivity in mice #MMPMID29259155 Hong H; Cui ZZ; Zhu L; Fu SP; Rossi M; Cui YH; Zhu BM Nutr Diabetes 2017[Dec]; 7 (12): ä PMID29259155show ga Insulin-like growth factor 1 (IGF1) is a key factor for tissue growth and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that IGF1 expression is increased in the hypothalamus of obese mice lacking STAT5 in the central nervous system (CNS). In this study, we explored the potential metabolic function of central IGF1 by intracerebroventricular (ICV) injection of IGF1, over-expression of central IGF1 by administering an adeno-associated virus (AAV), and ICV injection of an anti-IGF1 antibody. Mice that over-expressed central IGF1 displayed increased appetite, improved glucose tolerance and insulin sensitivity, decreased Pomc levels in the hypothalamus, and increased UCP1 expression in brown fat tissue. This is the first study demonstrating that central IGF1 regulates several important metabolic functions. äCentral IGF1 improves glucose tolerance and insulin sensitivity in mic(epmc).pdf DeepDyve Pubget Overpricing