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10.1038/s41387-017-0005-x http://scihub22266oqcxt.onion/10.1038/s41387-017-0005-x C5865546!5865546!29269872     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutr+Diabetes 2017 ; 7 (12): ä Nephropedia Template TP {{tp|p=29269872|t=2017. The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells |pdf=|usr=}}{{29269872}} gab.com Text The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells JO: Nutr Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=29269872 #FOAvip Free fatty acids (FFAs) can cause glucose intolerance and diabetes. Lipotoxicity to the pancreatic beta cells is considered to be a major underlying cause for this phenomenon. The aim of this study was to analyse the toxicity profile of FFAs in the human EndoC-?H1 beta-cell line and to compare the results with isolated rat and human islets with special reference to the physiologically most prevalent FFAs palmitic acid (PA) and oleic acid (OA). Toxicity after a 2-day incubation with the different FFAs was analysed by the caspase-3 assay and confirmed by the propidium iodide and annexin V staining tests. The long-chain saturated PA (C16:0) and the monounsaturated OA (C18:1) were both toxic to human EndoC-?H1 beta cells and pseudoislets, as well as to rat islets, and, as confirmed in a pilot experiment, also to human islets. Furthermore, OA provided no protection against the toxicity of PA. Likewise, elaidic acid (EA, the trans isomer of OA; trans-OA) was significantly toxic, in contrast to the non-metabolisable analogues methylated PA (MePA) and methylated OA (MeOA). Fatty acids with a chain length??< C16 were not toxic in EndoC-?H1 beta cells. Caspase-3 was also activated by linoleic acid (LA)(C18:2) but not by ?-linolenic acid (?-LNA)(C18:3). Overall, only long-chain FFAs with chain lengths? >?C14, which generate hydrogen peroxide in the peroxisomal beta-oxidation, were toxic. This conclusion is also supported by the toxicity of the branched-chain FFA pristanic acid, which is exclusively metabolised in the peroxisomal beta-oxidation. The lack of a protective effect of the monounsaturated fatty acid OA has important consequences for a beta-cell protective lipid composition of a diet. A cardioprotective diet with a high OA content does not fulfil this requirement. Twit Text FOAVip The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells ????Nutr Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=29269872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29269872 #FOAvip English Wikipedia <ref>{{Cite pmid|29269872}}</ref> The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells #MMPMID29269872 Plötz T; Krümmel B; Laporte A; Pingitore A; Persaud S; Jörns A; Elsner M; Mehmeti I; Lenzen S Nutr Diabetes 2017[Dec]; 7 (12): ä PMID29269872show ga Free fatty acids (FFAs) can cause glucose intolerance and diabetes. Lipotoxicity to the pancreatic beta cells is considered to be a major underlying cause for this phenomenon. The aim of this study was to analyse the toxicity profile of FFAs in the human EndoC-?H1 beta-cell line and to compare the results with isolated rat and human islets with special reference to the physiologically most prevalent FFAs palmitic acid (PA) and oleic acid (OA). Toxicity after a 2-day incubation with the different FFAs was analysed by the caspase-3 assay and confirmed by the propidium iodide and annexin V staining tests. The long-chain saturated PA (C16:0) and the monounsaturated OA (C18:1) were both toxic to human EndoC-?H1 beta cells and pseudoislets, as well as to rat islets, and, as confirmed in a pilot experiment, also to human islets. Furthermore, OA provided no protection against the toxicity of PA. Likewise, elaidic acid (EA, the trans isomer of OA; trans-OA) was significantly toxic, in contrast to the non-metabolisable analogues methylated PA (MePA) and methylated OA (MeOA). Fatty acids with a chain length??< C16 were not toxic in EndoC-?H1 beta cells. Caspase-3 was also activated by linoleic acid (LA)(C18:2) but not by ?-linolenic acid (?-LNA)(C18:3). Overall, only long-chain FFAs with chain lengths? >?C14, which generate hydrogen peroxide in the peroxisomal beta-oxidation, were toxic. This conclusion is also supported by the toxicity of the branched-chain FFA pristanic acid, which is exclusively metabolised in the peroxisomal beta-oxidation. The lack of a protective effect of the monounsaturated fatty acid OA has important consequences for a beta-cell protective lipid composition of a diet. A cardioprotective diet with a high OA content does not fulfil this requirement. äThe monounsaturated fatty acid oleate is the major physiological toxic(epmc).pdf DeepDyve Pubget Overpricing