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10.1177/2042098617719815 http://scihub22266oqcxt.onion/10.1177/2042098617719815 C5865464!5865464!29593860     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29593860&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ther+Adv+Drug+Saf 2017 ; 8 (10): 319-28 Nephropedia Template TP {{tp|p=29593860|t=2017. Potential drug?drug interactions with direct oral anticoagulants in elderly hospitalized patients |pdf=|usr=}}{{29593860}} gab.com Text Potential drug drug interactions with direct oral anticoagulants in elderly hospitalized patients JO: Ther Adv Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=29593860 #FOAvip Background:: To determine the prevalence and nature of potential drug?drug interactions (DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods:: This was a retrospective observational study. Inclusion criteria were: aged over 65 years; taking apixaban, rivaroxaban or dabigatran; and admitted to the Repatriation General Hospital between April 2014 and July 2015. A list of clinically relevant ?perpetrator? drugs was compiled from product information, the Australian Medicines Handbook, the Australian National Prescribing Service resources, and local health network guidelines. The prevalence and nature of potential DDIs with DOACs was determined by comparing inpatient drug charts with the list of perpetrator drugs. Results:: There were 122 patients in the study with a mean age of 82 years. Most patients had nonvalvular atrial fibrillation and were taking DOACs to prevent thrombotic stroke (83%). Overall, 45 patients (37%) had a total of 54 potential DDIs. Thirty-five patients had potential pharmacodynamic DDIs with antidepressants, nonsteroidal anti-inflammatory drugs and antiplatelets (35/122, 29%). Nineteen patients had potential pharmacokinetic DDIs (19/122, 16%). Of these, 68% (13/19) were taking drugs that increase DOAC plasma concentrations (amiodarone, erythromycin, diltiazem or verapamil) and 32% (6/19) were taking drugs that decrease DOAC plasma concentrations (carbamazepine, primidone or phenytoin). There were no cases of patients taking contraindicated interacting drugs. Discussion:: Potential DDIs with DOACs in elderly hospital inpatients are relatively common, particularly interactions that may increase the risk of bleeding. The risk?benefit ratio of DOACs in elderly patients on polypharmacy should always be carefully considered. Twit Text FOAVip Potential drug drug interactions with direct oral anticoagulants in elderly hospitalized patients ????Ther Adv Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=29593860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29593860 #FOAvip English Wikipedia <ref>{{Cite pmid|29593860}}</ref> Potential drug?drug interactions with direct oral anticoagulants in elderly hospitalized patients #MMPMID29593860 Forbes HL; Polasek TM Ther Adv Drug Saf 2017[Oct]; 8 (10): 319-28 PMID29593860show ga Background:: To determine the prevalence and nature of potential drug?drug interactions (DDIs) with direct oral anticoagulants (DOACs) in elderly hospitalized patients. Methods:: This was a retrospective observational study. Inclusion criteria were: aged over 65 years; taking apixaban, rivaroxaban or dabigatran; and admitted to the Repatriation General Hospital between April 2014 and July 2015. A list of clinically relevant ?perpetrator? drugs was compiled from product information, the Australian Medicines Handbook, the Australian National Prescribing Service resources, and local health network guidelines. The prevalence and nature of potential DDIs with DOACs was determined by comparing inpatient drug charts with the list of perpetrator drugs. Results:: There were 122 patients in the study with a mean age of 82 years. Most patients had nonvalvular atrial fibrillation and were taking DOACs to prevent thrombotic stroke (83%). Overall, 45 patients (37%) had a total of 54 potential DDIs. Thirty-five patients had potential pharmacodynamic DDIs with antidepressants, nonsteroidal anti-inflammatory drugs and antiplatelets (35/122, 29%). Nineteen patients had potential pharmacokinetic DDIs (19/122, 16%). Of these, 68% (13/19) were taking drugs that increase DOAC plasma concentrations (amiodarone, erythromycin, diltiazem or verapamil) and 32% (6/19) were taking drugs that decrease DOAC plasma concentrations (carbamazepine, primidone or phenytoin). There were no cases of patients taking contraindicated interacting drugs. Discussion:: Potential DDIs with DOACs in elderly hospital inpatients are relatively common, particularly interactions that may increase the risk of bleeding. The risk?benefit ratio of DOACs in elderly patients on polypharmacy should always be carefully considered. äPotential drug?drug interactions with direct oral anticoagulants in el(epmc).pdf DeepDyve Pubget Overpricing