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10.3389/fimmu.2018.00516 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00516 C5865411!5865411!29616030     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29616030|t=2018. Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10 |pdf=|usr=}}{{29616030}} gab.com Text Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29616030 #FOAvip Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation. Twit Text FOAVip Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29616030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29616030 #FOAvip English Wikipedia <ref>{{Cite pmid|29616030}}</ref> Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10 #MMPMID29616030 Lee SMY; Yip TF; Yan S; Jin DY; Wei HL; Guo RT; Peiris JSM Front Immunol 2018[]; 9 (ä): ä PMID29616030show ga Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation. äRecognition of Double-Stranded RNA and Regulation of Interferon Pathwa(epmc).pdf DeepDyve Pubget Overpricing