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10.1186/s12936-018-2274-9 http://scihub22266oqcxt.onion/10.1186/s12936-018-2274-9 C5865348!5865348!29566677     free     free     free       Malar+J 2018 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29566677|t=2018. Acidosis and acute kidney injury in severe malaria |pdf=|usr=}}{{29566677}} gab.com Text Acidosis and acute kidney injury in severe malaria JO: Malar J http://www.kidney.de/pget.php?&tw=1&pmid=29566677 #FOAvip Background: In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria. Methods: Plasma and urinary acids which previously showed increased concentrations in proportion to disease severity in patients with severe falciparum malaria were quantified. Patients with uncomplicated malaria, sepsis and healthy volunteers served as comparator groups. Multiple regression and multivariate analysis were used to assess the relationship between organic acid concentrations and clinical syndromes, in particular AKI. Results: Patients with severe malaria (n?=?90), uncomplicated malaria (n?=?94), non-malaria sepsis (n?=?19), and healthy volunteers (n?=?61) were included. Univariate analysis showed that both plasma and creatinine-adjusted urine concentrations of p-hydroxyphenyllactic acid (pHPLA) were higher in severe malaria patients with AKI (p?<?0.001). Multiple regression analysis, including plasma or creatinine-adjusted urinary acids, and PfHRP2 as parasite biomass marker as independent variables, showed that pHPLA was independently associated with plasma creatinine (??=?0.827) and urine creatinine (??=?0.226). Principal component analysis, including four plasma acids and seven urinary acids separated a group of patients with AKI, which was mainly driven by pHPLA concentrations. Conclusions: Both plasma and urine concentrations of pHPLA closely correlate with AKI in patients with severe falciparum malaria. Further studies will need to assess the potential nephrotoxic properties of pHPLA. Electronic supplementary material: The online version of this article (10.1186/s12936-018-2274-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip Acidosis and acute kidney injury in severe malaria ????Malar J http://www.kidney.de/pget.php?&tw=1&pmid=29566677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29566677 #FOAvip English Wikipedia <ref>{{Cite pmid|29566677}}</ref> Acidosis and acute kidney injury in severe malaria #MMPMID29566677 Sriboonvorakul N; Ghose A; Hassan MMU; Hossain MA; Faiz MA; Pukrittayakamee S; Chotivanich K; Sukthana Y; Leopold SJ; Plewes K; Day NPJ; White NJ; Tarning J; Dondorp AM Malar J 2018[]; 17 (ä): ä PMID29566677show ga Background: In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria. Methods: Plasma and urinary acids which previously showed increased concentrations in proportion to disease severity in patients with severe falciparum malaria were quantified. Patients with uncomplicated malaria, sepsis and healthy volunteers served as comparator groups. Multiple regression and multivariate analysis were used to assess the relationship between organic acid concentrations and clinical syndromes, in particular AKI. Results: Patients with severe malaria (n?=?90), uncomplicated malaria (n?=?94), non-malaria sepsis (n?=?19), and healthy volunteers (n?=?61) were included. Univariate analysis showed that both plasma and creatinine-adjusted urine concentrations of p-hydroxyphenyllactic acid (pHPLA) were higher in severe malaria patients with AKI (p? äAcidosis and acute kidney injury in severe malaria (epmc).pdf DeepDyve Pubget Overpricing