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10.1038/s41467-018-03620-2 http://scihub22266oqcxt.onion/10.1038/s41467-018-03620-2 C5865148!5865148 !29572471     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29572471 &cmd=llinks): Failed to open stream: HTTP request failed! 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BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus |pdf=|usr=}}{{29572471 }} gab.com Text BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29572471 #FOAvip BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of the more active BAFF 60-mer to favor the induction of the less active BAFF trimer through interaction with the flap region of BAFF. In addition, the belimumab HCDR3 loop mimics the DxL(V/L) motif of BAFF receptors, thereby binding to BAFF in a similar manner as endogenous BAFF receptors. Our data thus provides insights for the design of new drugs targeting BAFF for the treatment of autoimmune diseases. Twit Text FOAVip BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29572471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29572471 #FOAvip English Wikipedia <ref>{{Cite pmid|29572471 }}</ref> BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus #MMPMID29572471 Shin W ; Lee HT ; Lim H ; Lee SH ; Son JY ; Lee JU ; Yoo KY ; Ryu SE ; Rhie J ; Lee JY ; Heo YS Nat Commun 2018[Mar]; 9 (1 ): 1200 PMID29572471 show ga BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of the more active BAFF 60-mer to favor the induction of the less active BAFF trimer through interaction with the flap region of BAFF. In addition, the belimumab HCDR3 loop mimics the DxL(V/L) motif of BAFF receptors, thereby binding to BAFF in a similar manner as endogenous BAFF receptors. Our data thus provides insights for the design of new drugs targeting BAFF for the treatment of autoimmune diseases. |Amino Acid Motifs [MESH] |Antibodies, Monoclonal, Humanized/*pharmacology [MESH] |B-Cell Activating Factor/*antagonists & inhibitors/metabolism [MESH] |B-Cell Activation Factor Receptor/antagonists & inhibitors/metabolism [MESH] |B-Lymphocytes/immunology [MESH] |Chromatography, Gel [MESH] |Crystallography, X-Ray [MESH] |Epitopes/chemistry [MESH] |Humans [MESH] |Immunosuppressive Agents/pharmacology [MESH] |Ligands [MESH] |Lupus Erythematosus, Systemic/*drug therapy [MESH] |Mutation [MESH]BAFF-neutralizing interaction of belimumab related to its therapeutic (epmc).pdf DeepDyve Pubget Overpricing