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10.1038/s41467-018-03323-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-03323-8 C5865128!5865128!29572442     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29572442|t=2018. A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors |pdf=|usr=}}{{29572442}} gab.com Text A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29572442 #FOAvip The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a loop region designated the flap, which is dispensable for receptor binding. Here we show that the flap of BAFF has two functions. In addition to facilitating the formation of a highly active BAFF 60-mer as shown previously, it also converts binding of BAFF to TNFRSF13C (BAFFR) into a signaling event via oligomerization of individual BAFF-BAFFR complexes. Binding and activation of BAFFR can therefore be targeted independently to inhibit or activate the function of BAFF. Moreover, structural analyses suggest that the flap of BAFF 60-mer temporarily prevents binding of an anti-BAFF antibody (belimumab) but not of a decoy receptor (atacicept). The observed differences in profiles of BAFF inhibition may confer distinct biological and clinical efficacies to these therapeutically relevant inhibitors. Twit Text FOAVip A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29572442 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29572442 #FOAvip English Wikipedia <ref>{{Cite pmid|29572442}}</ref> A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors #MMPMID29572442 Vigolo M; Chambers MG; Willen L; Chevalley D; Maskos K; Lammens A; Tardivel A; Das D; Kowalczyk-Quintas C; Schuepbach-Mallepell S; Smulski CR; Eslami M; Rolink A; Hummler E; Samy E; Fomekong Nanfack Y; Mackay F; Liao M; Hess H; Jiang X; Schneider P Nat Commun 2018[]; 9 (ä): ä PMID29572442show ga The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a loop region designated the flap, which is dispensable for receptor binding. Here we show that the flap of BAFF has two functions. In addition to facilitating the formation of a highly active BAFF 60-mer as shown previously, it also converts binding of BAFF to TNFRSF13C (BAFFR) into a signaling event via oligomerization of individual BAFF-BAFFR complexes. Binding and activation of BAFFR can therefore be targeted independently to inhibit or activate the function of BAFF. Moreover, structural analyses suggest that the flap of BAFF 60-mer temporarily prevents binding of an anti-BAFF antibody (belimumab) but not of a decoy receptor (atacicept). The observed differences in profiles of BAFF inhibition may confer distinct biological and clinical efficacies to these therapeutically relevant inhibitors. äA loop region of BAFF controls B cell survival and regulates recogniti(epmc).pdf DeepDyve Pubget Overpricing