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10.14744/AnatolJCardiol.2018.95142 http://scihub22266oqcxt.onion/10.14744/AnatolJCardiol.2018.95142 C5864769!5864769 !29521313     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29521313 &cmd=llinks): Failed to open stream: HTTP request failed! 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Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells |pdf=|usr=}}{{29521313 }} gab.com Text Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells JO: Anatol J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=29521313 #FOAvip OBJECTIVE: Although differentially expressed circRNAs have been proposed to be closely associated with epithelial-mesenchymal transition (EMT), the roles of circRNAs remain unclear in endothelial-to-mesenchymal transition (EndMT), which is a subcategory of EMT. Herein, we characterized the expression and potential function of circRNAs during TGF-ß1-induced EndMT in rat coronary artery endothelial cells (CAEC). METHODS: High-throughput RNA sequencing was performed for unbiasedly profiling the expression of circRNAs. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analysis were performed using online forecasting databases. Real-time quantitative polymerase chain reaction (RT-qPCR) was used for confirming the circRNA expression obtained from the sequencing data. RESULTS: Among the candidated circRNAs, 102 circRNAs were differentially expressed, among which 66 circRNAs and 36 circRNAs were up-regulated and down-regulated, respectively, in TGF-ß1-treated rat CAEC. GO analysis findings revealed that numerous differentially expressed circRNAs were closely associated with the biological process. KEGG signaling pathway analysis suggested that the abnormal expression of circRNAs had been implicated in regulating the dynamics endothelial cell junctions. Furthermore, we also found that three EndMT-related circRNAs, chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870, were significantly up-regulated in TGF-ß1-treated rat CAEC. CONCLUSION: The findings of this study reveal a comprehensive expression and potential functions of differentially expressed circRNAs during TGF-ß1-induced EndMT. These findings provide mechanistic insights into the role of circRNAs in EndMT-related cardiovascular diseases (CVDs). Twit Text FOAVip Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells ????Anatol J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=29521313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29521313 #FOAvip English Wikipedia <ref>{{Cite pmid|29521313 }}</ref> Identification of differentially expressed circular RNAs during TGF-ß1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells #MMPMID29521313 Huang X ; Chen Y ; Xiao J ; Huang Z ; He L ; Xu D ; Peng J Anatol J Cardiol 2018[Mar]; 19 (3 ): 192-197 PMID29521313 show ga OBJECTIVE: Although differentially expressed circRNAs have been proposed to be closely associated with epithelial-mesenchymal transition (EMT), the roles of circRNAs remain unclear in endothelial-to-mesenchymal transition (EndMT), which is a subcategory of EMT. Herein, we characterized the expression and potential function of circRNAs during TGF-ß1-induced EndMT in rat coronary artery endothelial cells (CAEC). METHODS: High-throughput RNA sequencing was performed for unbiasedly profiling the expression of circRNAs. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analysis were performed using online forecasting databases. Real-time quantitative polymerase chain reaction (RT-qPCR) was used for confirming the circRNA expression obtained from the sequencing data. RESULTS: Among the candidated circRNAs, 102 circRNAs were differentially expressed, among which 66 circRNAs and 36 circRNAs were up-regulated and down-regulated, respectively, in TGF-ß1-treated rat CAEC. GO analysis findings revealed that numerous differentially expressed circRNAs were closely associated with the biological process. KEGG signaling pathway analysis suggested that the abnormal expression of circRNAs had been implicated in regulating the dynamics endothelial cell junctions. Furthermore, we also found that three EndMT-related circRNAs, chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870, were significantly up-regulated in TGF-ß1-treated rat CAEC. CONCLUSION: The findings of this study reveal a comprehensive expression and potential functions of differentially expressed circRNAs during TGF-ß1-induced EndMT. These findings provide mechanistic insights into the role of circRNAs in EndMT-related cardiovascular diseases (CVDs). |Animals [MESH] |Coronary Vessels/*cytology [MESH] |Endothelial Cells/*drug effects [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Male [MESH] |RNA, Circular [MESH] |RNA/genetics [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Identification of differentially expressed circular RNAs during TGF-ß1(epmc).pdf DeepDyve Pubget Overpricing