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10.1038/s41418-017-0040-0 http://scihub22266oqcxt.onion/10.1038/s41418-017-0040-0 C5864232!5864232!29352263     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2018 ; 25 (3): 471-6 Nephropedia Template TP {{tp|p=29352263|t=2018. Mammalian endoreplication emerges to reveal a potential developmental timer |pdf=|usr=}}{{29352263}} gab.com Text Mammalian endoreplication emerges to reveal a potential developmental timer JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=29352263 #FOAvip Among the most intriguing and relevant questions in physiology is how developing tissues correctly coordinate proliferation with differentiation. Endoreplication, in a broad sense, is a consequence of a cell division block in the presence of an active cell cycle, and it typically occurs as cells differentiate terminally to fulfill a specialised function. Until recently, endoreplication was thought to be a rare variation of the cell cycle in mammals, more common in invertebrates and plants. However, in the last years, endoreplication has been uncovered in various tissues in mammalian organisms, including human. A recent report showing that cells in the mammary gland become binucleate at lactation sheds new insight into the importance of mammalian polyploidisation. We here propose that endoreplication is a widespread phenomenon in mammalian developing tissues that results from an automatic, robust and simple self-limiting mechanism coordinating cell multiplication with differentiation. This mechanism might act as a developmental timer. The model has implications for homeostasis control and carcinogenesis. Twit Text FOAVip Mammalian endoreplication emerges to reveal a potential developmental timer ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=29352263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29352263 #FOAvip English Wikipedia <ref>{{Cite pmid|29352263}}</ref> Mammalian endoreplication emerges to reveal a potential developmental timer #MMPMID29352263 Gandarillas A; Molinuevo R; Sanz-Gómez N Cell Death Differ 2018[Mar]; 25 (3): 471-6 PMID29352263show ga Among the most intriguing and relevant questions in physiology is how developing tissues correctly coordinate proliferation with differentiation. Endoreplication, in a broad sense, is a consequence of a cell division block in the presence of an active cell cycle, and it typically occurs as cells differentiate terminally to fulfill a specialised function. Until recently, endoreplication was thought to be a rare variation of the cell cycle in mammals, more common in invertebrates and plants. However, in the last years, endoreplication has been uncovered in various tissues in mammalian organisms, including human. A recent report showing that cells in the mammary gland become binucleate at lactation sheds new insight into the importance of mammalian polyploidisation. We here propose that endoreplication is a widespread phenomenon in mammalian developing tissues that results from an automatic, robust and simple self-limiting mechanism coordinating cell multiplication with differentiation. This mechanism might act as a developmental timer. The model has implications for homeostasis control and carcinogenesis. äMammalian endoreplication emerges to reveal a potential developmental (epmc).pdf DeepDyve Pubget Overpricing