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10.1371/journal.pone.0194679 http://scihub22266oqcxt.onion/10.1371/journal.pone.0194679 C5864059!5864059 !29566045     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29566045 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2018 ; 13 (3 ): e0194679 Nephropedia Template TP {{tp|p=29566045 |t=2018. TGF-?1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels |pdf=|usr=}}{{29566045 }} gab.com Text TGF- 1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29566045 #FOAvip Cell-based strategies for the treatment of ischemic diseases are at the forefront of tissue engineering and regenerative medicine. Cell therapies purportedly can play a key role in the neovascularization of ischemic tissue; however, low survival and poor cell engraftment with the host vasculature following implantation limits their potential to treat ischemic diseases. To overcome these limitations, we previously developed a growth factor sequestering hyaluronic acid (HyA)-based hydrogel that enhanced transplanted mouse cardiosphere-derived cell survival and formation of vasculature that anastomosed with host vessels. In this work, we examined the mechanism by which HyA hydrogels presenting transforming growth factor beta-1 (TGF-?1) promoted proliferation of more clinically relevant human cardiosphere-derived cells (hCDC), and their formation of vascular-like networks in vitro. We observed hCDC proliferation and enhanced formation of vascular-like networks occurred in the presence of TGF-?1. Furthermore, production of nitric oxide (NO), VEGF, and a host of angiogenic factors were increased in the presence of TGF-?1. This response was dependent on the co-activity of CD105 (Endoglin) with the TGF-?R2 receptor, demonstrating its role in the process of angiogenic differentiation and vascular organization of hCDC. These results demonstrated that hCDC form vascular-like networks in vitro, and that the induction of vascular networks by hCDC within growth factor sequestering HyA hydrogels was mediated by TGF-?1/CD105 signaling. Twit Text FOAVip TGF- 1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29566045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29566045 #FOAvip English Wikipedia <ref>{{Cite pmid|29566045 }}</ref> TGF-?1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels #MMPMID29566045 Browne S ; Jha AK ; Ameri K ; Marcus SG ; Yeghiazarians Y ; Healy KE PLoS One 2018[]; 13 (3 ): e0194679 PMID29566045 show ga Cell-based strategies for the treatment of ischemic diseases are at the forefront of tissue engineering and regenerative medicine. Cell therapies purportedly can play a key role in the neovascularization of ischemic tissue; however, low survival and poor cell engraftment with the host vasculature following implantation limits their potential to treat ischemic diseases. To overcome these limitations, we previously developed a growth factor sequestering hyaluronic acid (HyA)-based hydrogel that enhanced transplanted mouse cardiosphere-derived cell survival and formation of vasculature that anastomosed with host vessels. In this work, we examined the mechanism by which HyA hydrogels presenting transforming growth factor beta-1 (TGF-?1) promoted proliferation of more clinically relevant human cardiosphere-derived cells (hCDC), and their formation of vascular-like networks in vitro. We observed hCDC proliferation and enhanced formation of vascular-like networks occurred in the presence of TGF-?1. Furthermore, production of nitric oxide (NO), VEGF, and a host of angiogenic factors were increased in the presence of TGF-?1. This response was dependent on the co-activity of CD105 (Endoglin) with the TGF-?R2 receptor, demonstrating its role in the process of angiogenic differentiation and vascular organization of hCDC. These results demonstrated that hCDC form vascular-like networks in vitro, and that the induction of vascular networks by hCDC within growth factor sequestering HyA hydrogels was mediated by TGF-?1/CD105 signaling. |*Endothelial Cells/cytology/drug effects/physiology [MESH] |*Hydrogels/chemistry/metabolism [MESH] |*Neovascularization, Physiologic/drug effects/physiology [MESH] |Cell Differentiation/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Cell- and Tissue-Based Therapy/instrumentation/methods [MESH] |Cells, Cultured [MESH] |Drug Compounding/methods [MESH] |Endoglin/*metabolism [MESH] |Humans [MESH] |Hyaluronic Acid/*chemistry [MESH] |Myocardium/cytology/metabolism [MESH] |Myocytes, Cardiac/cytology/drug effects/physiology [MESH] |Signal Transduction/drug effects [MESH] |Spheroids, Cellular/*cytology/drug effects/metabolism [MESH] |Tissue Scaffolds/chemistry [MESH]TGF-?1/CD105 signaling controls vascular network formation within grow(epmc).pdf DeepDyve Pubget Overpricing