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10.1371/journal.pone.0188299

http://scihub22266oqcxt.onion/10.1371/journal.pone.0188299
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C5863943!5863943!29565985
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suck abstract from ncbi


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pmid29565985      PLoS+One 2018 ; 13 (3): ä
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  • Second-generation p-values: Improved rigor, reproducibility, & transparency in statistical analyses #MMPMID29565985
  • Blume JD; D?Agostino McGowan L; Dupont WD; Greevy RA
  • PLoS One 2018[]; 13 (3): ä PMID29565985show ga
  • Verifying that a statistically significant result is scientifically meaningful is not only good scientific practice, it is a natural way to control the Type I error rate. Here we introduce a novel extension of the p-value?a second-generation p-value (p?)?that formally accounts for scientific relevance and leverages this natural Type I Error control. The approach relies on a pre-specified interval null hypothesis that represents the collection of effect sizes that are scientifically uninteresting or are practically null. The second-generation p-value is the proportion of data-supported hypotheses that are also null hypotheses. As such, second-generation p-values indicate when the data are compatible with null hypotheses (p? = 1), or with alternative hypotheses (p? = 0), or when the data are inconclusive (0 < p? < 1). Moreover, second-generation p-values provide a proper scientific adjustment for multiple comparisons and reduce false discovery rates. This is an advance for environments rich in data, where traditional p-value adjustments are needlessly punitive. Second-generation p-values promote transparency, rigor and reproducibility of scientific results by a priori specifying which candidate hypotheses are practically meaningful and by providing a more reliable statistical summary of when the data are compatible with alternative or null hypotheses.
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