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10.1186/s13075-018-1559-2 http://scihub22266oqcxt.onion/10.1186/s13075-018-1559-2 C5863897!5863897!29566736     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Res+Ther 2018 ; 20 (ä): ä Nephropedia Template TP {{tp|p=29566736|t=2018. Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort |pdf=|usr=}}{{29566736}} gab.com Text Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29566736 #FOAvip Background: Diuretics have been associated with impaired response and refractoriness in gout, but whether this effect is still present with new urate-lowering drugs (ULD) and treat-to-target strategies is unknown. The aim of the present study was to assess the impact of the diuretics on the response to ULD in patients with gout.  Methods: This was a retrospective analysis of an inception cohort. Participants were classified according to the type of ULD prescribed. We analysed the maximal dose of ULD (primary outcome variable), serum urate (SU) reduction, and the achievement of different SU targets (6 mg/dL, 5 mg/dL, and 4 mg/dL), according to the type of ULD prescribed and use of diuretics (loop and/or thiazide). We adjusted for confounders using multiple linear regression analysis. Results: We included 245 patients: 208 treated with allopurinol (66 on diuretics, 31.7%), 35 with febuxostat (19 on diuretics, 57.6%), and 2 with benzbromarone. Significantly fewer participants in the allopurinol plus diuretics subgroup achieved SU levels of less than 5 mg/dL, but we found no other significant differences in SU targets associated with diuretics. Regarding the maximum ULD dose, a simple linear regression suggested an inverse relationship with diuretics (beta = ??0.125, p = 0.073), but this did not hold in the multivariable analysis (beta = ??0.47, p = 0.833). There was no association with febuxostat (beta = ??0.116, p = 0.514). Conclusion: Diuretics do not appear to have a significant impact on managing gout. Electronic supplementary material: The online version of this article (10.1186/s13075-018-1559-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=29566736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29566736 #FOAvip English Wikipedia <ref>{{Cite pmid|29566736}}</ref> Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort #MMPMID29566736 Ranieri L; Contero C; Peral ML; Calabuig I; Zapater P; Andres M Arthritis Res Ther 2018[]; 20 (ä): ä PMID29566736show ga Background: Diuretics have been associated with impaired response and refractoriness in gout, but whether this effect is still present with new urate-lowering drugs (ULD) and treat-to-target strategies is unknown. The aim of the present study was to assess the impact of the diuretics on the response to ULD in patients with gout.  Methods: This was a retrospective analysis of an inception cohort. Participants were classified according to the type of ULD prescribed. We analysed the maximal dose of ULD (primary outcome variable), serum urate (SU) reduction, and the achievement of different SU targets (6 mg/dL, 5 mg/dL, and 4 mg/dL), according to the type of ULD prescribed and use of diuretics (loop and/or thiazide). We adjusted for confounders using multiple linear regression analysis. Results: We included 245 patients: 208 treated with allopurinol (66 on diuretics, 31.7%), 35 with febuxostat (19 on diuretics, 57.6%), and 2 with benzbromarone. Significantly fewer participants in the allopurinol plus diuretics subgroup achieved SU levels of less than 5 mg/dL, but we found no other significant differences in SU targets associated with diuretics. Regarding the maximum ULD dose, a simple linear regression suggested an inverse relationship with diuretics (beta = ??0.125, p = 0.073), but this did not hold in the multivariable analysis (beta = ??0.47, p = 0.833). There was no association with febuxostat (beta = ??0.116, p = 0.514). Conclusion: Diuretics do not appear to have a significant impact on managing gout. Electronic supplementary material: The online version of this article (10.1186/s13075-018-1559-2) contains supplementary material, which is available to authorized users. äImpact of diuretics on the urate lowering therapy in patients with gou(epmc).pdf DeepDyve Pubget Overpricing