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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Pharmacol
2010 ; 59
(ä): 197-233
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Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2
and angiotensin-(1-7)
#MMPMID20933203
Ferrario CM
; Ahmad S
; Joyner J
; Varagic J
Adv Pharmacol
2010[]; 59
(ä): 197-233
PMID20933203
show ga
The contribution of the renin angiotensin system to physiology and pathology is
undergoing a rapid reconsideration of its mechanisms from emerging new concepts
implicating angiotensin-converting enzyme 2 and angiotensin-(1-7) as new elements
negatively influencing the vasoconstrictor, trophic, and pro-inflammatory actions
of angiotensin II. This component of the system acts to oppose the
vasoconstrictor and proliferative effects on angiotensin II through signaling
mechanisms mediated by the mas receptor. In addition, a reduced expression of the
vasodepressor axis composed by angiotensin-converting enzyme 2 and
angiotensin-(1-7) may contribute to the expression of essential hypertension, the
remodeling of heart and renal function associated with this disease, and even the
physiology of pregnancy and the development of eclampsia.