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10.1007/978-3-319-63245-2_6 http://scihub22266oqcxt.onion/10.1007/978-3-319-63245-2_6 C5863727!5863727 !29047082     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29047082 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Adv+Exp+Med+Biol 2017 ; 967 (?): 71-81 Nephropedia Template TP {{tp|p=29047082 |t=2017. A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension |pdf=|usr=}}{{29047082 }} gab.com Text A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=29047082 #FOAvip Pulmonary hypertension (PH) is characterized by increased vasoconstriction and smooth muscle cell hyperplasia driving pathological vascular remodeling of arterial vessels. In this short review, we discuss the primary source of reactive oxygen species (ROS) and nitric oxide (NO) relevant to PH and the mechanism by which dysregulation of their production contributes to PH. Specifically, hypoxia-induced PH is associated with diminished endothelial nitric oxide synthase (eNOS)-derived NO production and increased production of superoxide (O(2)(?-)) through eNOS uncoupling and defective mitochondrial respiration. This drives the inhibition of the NO/soluble guanylate cyclase (sGC) pathway and activation of the transcription factor hypoxia-inducible factor-1? (HIF-1?) with consequential dysregulation of the pulmonary vasculature. Therapeutics aimed at increasing NO or cGMP bioavailabilities are amenable to hypoxia disease-induced PH. Similarly, strategies targeting HIF-1? are now considered. Overall, pulmonary hypertension including hypoxia-induced PH offers unique opportunities for the rational development of therapeutics centered on modulating redox signaling. Twit Text FOAVip A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=29047082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29047082 #FOAvip English Wikipedia <ref>{{Cite pmid|29047082 }}</ref> A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension #MMPMID29047082 Jaitovich A ; Jourd'heuil D Adv Exp Med Biol 2017[]; 967 (?): 71-81 PMID29047082 show ga Pulmonary hypertension (PH) is characterized by increased vasoconstriction and smooth muscle cell hyperplasia driving pathological vascular remodeling of arterial vessels. In this short review, we discuss the primary source of reactive oxygen species (ROS) and nitric oxide (NO) relevant to PH and the mechanism by which dysregulation of their production contributes to PH. Specifically, hypoxia-induced PH is associated with diminished endothelial nitric oxide synthase (eNOS)-derived NO production and increased production of superoxide (O(2)(?-)) through eNOS uncoupling and defective mitochondrial respiration. This drives the inhibition of the NO/soluble guanylate cyclase (sGC) pathway and activation of the transcription factor hypoxia-inducible factor-1? (HIF-1?) with consequential dysregulation of the pulmonary vasculature. Therapeutics aimed at increasing NO or cGMP bioavailabilities are amenable to hypoxia disease-induced PH. Similarly, strategies targeting HIF-1? are now considered. Overall, pulmonary hypertension including hypoxia-induced PH offers unique opportunities for the rational development of therapeutics centered on modulating redox signaling. |*Signal Transduction [MESH] |Animals [MESH] |Humans [MESH] |Hypertension, Pulmonary/*metabolism/physiopathology [MESH] |Hypoxia [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH] |Nitric Oxide Synthase Type III/metabolism [MESH] |Nitric Oxide/*metabolism [MESH] |Reactive Oxygen Species/*metabolism [MESH]A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling(epmc).pdf DeepDyve Pubget Overpricing