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10.1038/s41467-018-03258-0 http://scihub22266oqcxt.onion/10.1038/s41467-018-03258-0 C5862842!5862842!29563502     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29563502|t=2018. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum |pdf=|usr=}}{{29563502}} gab.com Text Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29563502 #FOAvip Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3?2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p?<?5?×?10?8) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease. Twit Text FOAVip Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29563502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29563502 #FOAvip English Wikipedia <ref>{{Cite pmid|29563502}}</ref> Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum #MMPMID29563502 Fejzo MS; Sazonova OV; Sathirapongsasuti JF; Hallgrímsdóttir IB; Vacic V; MacGibbon KW; Schoenberg FP; Mancuso N; Slamon DJ; Mullin PM Nat Commun 2018[]; 9 (ä): ä PMID29563502show ga Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3?2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p? äPlacenta and appetite genes GDF15 and IGFBP7 are associated with hyper(epmc).pdf DeepDyve Pubget Overpricing