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10.18632/oncotarget.24179 http://scihub22266oqcxt.onion/10.18632/oncotarget.24179 C5862632!5862632!29568411     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (17): 13991-4004 Nephropedia Template TP {{tp|p=29568411|t=2018. The development of CAR design for tumor CAR-T cell therapy |pdf=|usr=}}{{29568411}} gab.com Text The development of CAR design for tumor CAR-T cell therapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568411 #FOAvip In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the development of extracellular antigen recognition receptors, intracellular co-stimulatory molecules and the combination application of CARs and synthetic small molecules. In addition, effects on the function of the CAR-T cells that the space distance between the antigen binding domains and tumor targets and the length of the spacer domains have are also being investigated. Given the fast-moving nature of this field, it is necessary to make a summary of the development of CAR-T cells. In this review, we mainly focus on the present design strategies of CAR-T cells with the hope that they can provide insights to increase the anti-tumor efficacy and safety. Twit Text FOAVip The development of CAR design for tumor CAR-T cell therapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568411 #FOAvip English Wikipedia <ref>{{Cite pmid|29568411}}</ref> The development of CAR design for tumor CAR-T cell therapy #MMPMID29568411 Xu D; Jin G; Chai D; Zhou X; Gu W; Chong Y; Song J; Zheng J Oncotarget 2018[Mar]; 9 (17): 13991-4004 PMID29568411show ga In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the development of extracellular antigen recognition receptors, intracellular co-stimulatory molecules and the combination application of CARs and synthetic small molecules. In addition, effects on the function of the CAR-T cells that the space distance between the antigen binding domains and tumor targets and the length of the spacer domains have are also being investigated. Given the fast-moving nature of this field, it is necessary to make a summary of the development of CAR-T cells. In this review, we mainly focus on the present design strategies of CAR-T cells with the hope that they can provide insights to increase the anti-tumor efficacy and safety. äThe development of CAR design for tumor CAR-T cell therapy (epmc).pdf DeepDyve Pubget Overpricing