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10.18632/oncotarget.24422 http://scihub22266oqcxt.onion/10.18632/oncotarget.24422 C5862599!5862599!29568378     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (17): 13565-81 Nephropedia Template TP {{tp|p=29568378|t=2018. Human tripartite motif protein 52 is required for cell context-dependent proliferation |pdf=|usr=}}{{29568378}} gab.com Text Human tripartite motif protein 52 is required for cell context-dependent proliferation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568378 #FOAvip Tripartite motif (TRIM) proteins have been shown to play important roles in cancer development and progression by modulating cell proliferation or resistance from cell death during non-homeostatic stress conditions found in tumor micro-environments. In this study, we set out to investigate the importance for cellular fitness of the virtually uncharacterized family member TRIM52.The human TRIM52 gene has arisen recently in evolution, making it unlikely that TRIM52 is required for basic cellular functions in normal cells. However, a recent genome-wide ablation screening study has suggested that TRIM52 may be essential for optimal proliferation or survival in certain genetic cancer backgrounds. Identifying genes which fit this concept of genetic context-dependent fitness in cancer cells is of interest as they are promising targets for tumor-specific therapy.We report here that TRIM52 ablation significantly diminished the proliferation of specific glioblastoma cell lines in cell culture and mouse xenografts by compromising their cell cycle progression in a p53-dependent manner. Together, our findings point to a non-redundant TRIM52 function that is required for optimal proliferation. Twit Text FOAVip Human tripartite motif protein 52 is required for cell context-dependent proliferation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568378 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568378 #FOAvip English Wikipedia <ref>{{Cite pmid|29568378}}</ref> Human tripartite motif protein 52 is required for cell context-dependent proliferation #MMPMID29568378 Benke S; Agerer B; Haas L; Stöger M; Lercher A; Gabler L; Kiss I; Scinicariello S; Berger W; Bergthaler A; Obenauf AC; Versteeg GA Oncotarget 2018[Mar]; 9 (17): 13565-81 PMID29568378show ga Tripartite motif (TRIM) proteins have been shown to play important roles in cancer development and progression by modulating cell proliferation or resistance from cell death during non-homeostatic stress conditions found in tumor micro-environments. In this study, we set out to investigate the importance for cellular fitness of the virtually uncharacterized family member TRIM52.The human TRIM52 gene has arisen recently in evolution, making it unlikely that TRIM52 is required for basic cellular functions in normal cells. However, a recent genome-wide ablation screening study has suggested that TRIM52 may be essential for optimal proliferation or survival in certain genetic cancer backgrounds. Identifying genes which fit this concept of genetic context-dependent fitness in cancer cells is of interest as they are promising targets for tumor-specific therapy.We report here that TRIM52 ablation significantly diminished the proliferation of specific glioblastoma cell lines in cell culture and mouse xenografts by compromising their cell cycle progression in a p53-dependent manner. Together, our findings point to a non-redundant TRIM52 function that is required for optimal proliferation. äHuman tripartite motif protein 52 is required for cell context-depende(epmc).pdf DeepDyve Pubget Overpricing