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10.18632/oncotarget.24385 http://scihub22266oqcxt.onion/10.18632/oncotarget.24385 C5862586!5862586!29568365     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (17): 13390-406 Nephropedia Template TP {{tp|p=29568365|t=2018. Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224 |pdf=|usr=}}{{29568365}} gab.com Text Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568365 #FOAvip Amiodarone is a widely used class III antiarrhythmic agent which prolongs the action potential and refractory period by blockage of several types of myocardial potassium channels. Emerging evidence suggests that amiodarone sensitize tumor cells in response to chemotherapy. Nevertheless, little is known about the underlying molecular mechanism. To gain further insight, we demonstrated that amiodarone accumulated the population of a premature termination codon-containing isoform of serine and arginine rich splicing factor 3 (SRSF3-PTC) without increasing alternative spliced p53 beta isoform. Amiodarone enhanced reactive oxygen species production and increased cell apoptosis, whereas reduced DNA damage. Moreover, amiodarone suppressed miR-224 and increased its target COX-2 expression. Taken together, our results suggested amiodarone caused cancer cell death might be through increased SRSF3-PTC and miR-224 reduction in a p53-independent manner. Twit Text FOAVip Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29568365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568365 #FOAvip English Wikipedia <ref>{{Cite pmid|29568365}}</ref> Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224 #MMPMID29568365 Chang YL; Liu ST; Wang YW; Lin WS; Huang SM Oncotarget 2018[Mar]; 9 (17): 13390-406 PMID29568365show ga Amiodarone is a widely used class III antiarrhythmic agent which prolongs the action potential and refractory period by blockage of several types of myocardial potassium channels. Emerging evidence suggests that amiodarone sensitize tumor cells in response to chemotherapy. Nevertheless, little is known about the underlying molecular mechanism. To gain further insight, we demonstrated that amiodarone accumulated the population of a premature termination codon-containing isoform of serine and arginine rich splicing factor 3 (SRSF3-PTC) without increasing alternative spliced p53 beta isoform. Amiodarone enhanced reactive oxygen species production and increased cell apoptosis, whereas reduced DNA damage. Moreover, amiodarone suppressed miR-224 and increased its target COX-2 expression. Taken together, our results suggested amiodarone caused cancer cell death might be through increased SRSF3-PTC and miR-224 reduction in a p53-independent manner. äAmiodarone promotes cancer cell death through elevated truncated SRSF3(epmc).pdf DeepDyve Pubget Overpricing