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10.1093/carcin/bgw127

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suck abstract from ncbi


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pmid27993896      Carcinogenesis 2017 ; 38 (2): 119-33
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  • Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect #MMPMID27993896
  • San-Millán I; Brooks GA
  • Carcinogenesis 2017[Feb]; 38 (2): 119-33 PMID27993896show ga
  • By reversing emphasis from precursor uptake to product accumulation and release, we posit that lactate production (?lactagenesis?) supports carcinogenesis and it is the explanation and purpose of the Warburg effect. We posit that in carcinogenesis, aberrant cell signaling due to exaggerated and continually high lactate levels yields an inappropriate positive feedback loop that increases glucose uptake, glycolysis, lactate production and release, decreases mitochondrial function and clearance and upregulates glycolytic enzyme and monocarboxylate transporter expression thereby supporting angiogenesis, immune escape, cell migration, metastasis and self-sufficient metabolism, all of which encourage progression to cancer.
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