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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Carcinogenesis 2017 ; 38 (2): 119-33 Nephropedia Template TP
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Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect #MMPMID27993896
San-Millán I; Brooks GA
Carcinogenesis 2017[Feb]; 38 (2): 119-33 PMID27993896show ga
By reversing emphasis from precursor uptake to product accumulation and release, we posit that lactate production (?lactagenesis?) supports carcinogenesis and it is the explanation and purpose of the Warburg effect. We posit that in carcinogenesis, aberrant cell signaling due to exaggerated and continually high lactate levels yields an inappropriate positive feedback loop that increases glucose uptake, glycolysis, lactate production and release, decreases mitochondrial function and clearance and upregulates glycolytic enzyme and monocarboxylate transporter expression thereby supporting angiogenesis, immune escape, cell migration, metastasis and self-sufficient metabolism, all of which encourage progression to cancer.