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10.1093/carcin/bgx050

http://scihub22266oqcxt.onion/10.1093/carcin/bgx050
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C5862323!5862323!28535186
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suck abstract from ncbi


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pmid28535186      Carcinogenesis 2017 ; 38 (7): 738-47
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  • FXR-Gankyrin axis is involved in development of pediatric liver cancer #MMPMID28535186
  • Valanejad L; Lewis K; Wright M; Jiang Y; D?Souza A; Karns R; Sheridan R; Gupta A; Bove K; Witte D; Geller J; Tiao G; Nelson DL; Timchenko L; Timchenko N
  • Carcinogenesis 2017[Jul]; 38 (7): 738-47 PMID28535186show ga
  • Tumor suppressor proteins protect liver from development of cancer. We have found that the tumor suppressor proteins are eliminated in hepatoblastoma by a small subunit of proteasome Gankyrin. This elimination of TSPs causes a failure of stem cells to differentiate into hepatocytes leading to development of hepatoblastoma.
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