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10.4161/auto.25880 http://scihub22266oqcxt.onion/10.4161/auto.25880 C5862144!5862144!24004837     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2013 ; 9 (10): 1629-30 Nephropedia Template TP {{tp|p=24004837|t=2013. Signalphagy: Scheduled signal termination by macroautophagy |pdf=|usr=}}{{24004837}} gab.com Text Signalphagy: Scheduled signal termination by macroautophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24004837 #FOAvip A fundamental issue in cell biology is how the activation of a signaling pathway should lead to the appropriate cell response. Because of their oncogenic potential, the abundance, the duration and the localization of key signaling proteins must be carefully controlled. Negative feedback loops that combine transcription and protein?protein interactions are among the strategies by which a cell can turn off signaling. Our recent studies in Cancer Research and Autophagy show that degradation of key active proteins such as RHOA-GTP by constitutive autophagy represents one safeguard mechanism that limits signaling in a spatially and temporally restricted manner for faithful cytokinesis and directed migration. As a result, all autophagy compromises drive cytokinesis failure, aneuploidy, and motility?three processes that directly have an impact upon cancer progression. We therefore propose the term ?signalphagy? to indicate a dedicated type of macroautophagy that degrades and thereby maintains the appropriate level of active signaling proteins to achieve tumor suppression. Twit Text FOAVip Signalphagy: Scheduled signal termination by macroautophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24004837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24004837 #FOAvip English Wikipedia <ref>{{Cite pmid|24004837}}</ref> Signalphagy: Scheduled signal termination by macroautophagy #MMPMID24004837 Belaid A; Ndiaye PD; Klionsky DJ; Hofman P; Mograbi B Autophagy 2013[Oct]; 9 (10): 1629-30 PMID24004837show ga A fundamental issue in cell biology is how the activation of a signaling pathway should lead to the appropriate cell response. Because of their oncogenic potential, the abundance, the duration and the localization of key signaling proteins must be carefully controlled. Negative feedback loops that combine transcription and protein?protein interactions are among the strategies by which a cell can turn off signaling. Our recent studies in Cancer Research and Autophagy show that degradation of key active proteins such as RHOA-GTP by constitutive autophagy represents one safeguard mechanism that limits signaling in a spatially and temporally restricted manner for faithful cytokinesis and directed migration. As a result, all autophagy compromises drive cytokinesis failure, aneuploidy, and motility?three processes that directly have an impact upon cancer progression. We therefore propose the term ?signalphagy? to indicate a dedicated type of macroautophagy that degrades and thereby maintains the appropriate level of active signaling proteins to achieve tumor suppression. äSignalphagy: Scheduled signal termination by macroautophagy (epmc).pdf DeepDyve Pubget Overpricing