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Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus
aureus Colonization of Venous Catheters
#MMPMID29489705
Kowalewska PM
; Petrik SM
; Di Fiore AE
; Fox-Robichaud AE
J Infus Nurs
2018[Mar]; 41
(2
): 103-112
PMID29489705
show ga
Vascular catheters are a major cause of nosocomial bloodstream infections.
ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical,
Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine
digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter
lumen during locking. The objective of this study was to evaluate the
antimicrobial efficacy of ChloraLock with in vitro tests and its ability to
reduce Staphylococcus aureus contamination of catheters in the external jugular
veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in
the in vitro tests by up to 6 log10 colony-forming units (CFU) and by 3 to 4
log10 CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.
|*Catheterization, Central Venous/adverse effects/instrumentation
[MESH]