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10.1093/ajh/hpx004 http://scihub22266oqcxt.onion/10.1093/ajh/hpx004 C5861585!5861585 !28199472     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28199472 &cmd=llinks): Failed to open stream: HTTP request failed! 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Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study |pdf=|usr=}}{{28199472 }} gab.com Text Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study JO: Am J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=28199472 #FOAvip BACKGROUND: The role of rare variants in blood pressure (BP) salt-sensitivity is unknown. We conducted a resequencing study of the renin-angiotensin-aldosterone system (RAAS) to identify rare variants associated with BP salt-sensitivity among participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. METHODS: The GenSalt study was conducted among 1,906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium feeding study (307.8 mmol sodium/day). The 300 most salt-sensitive and 300 most salt-resistant GenSalt participants were selected for the resequencing study. Seven RAAS genes were resequenced using capillary-based sequencing methods. Rare variants were tested for association with BP salt-sensitivity using traditional burden tests. Single-marker analyses were employed to test associations of low-frequency and common variants. RESULTS: Aggregate rare variant analysis revealed an association of the RAAS pathway with BP salt-sensitivity. Carriers of rare RAAS variants had a 1.55-fold [95% confidence interval (CI): 1.15, 2.10] higher odds of salt-sensitivity compared to noncarriers (P = 0.004), a finding which was significant after Bonferroni correction. A nominal association of the APLN gene with salt-sensitivity was also identified, with rare APLN variants conferring a 2.22-fold (95% CI: 1.05, 6.58) higher odds of salt-sensitivity (P = 0.03). Single-marker analyses did not identify variant-BP salt-sensitivity associations after Bonferroni adjustment. A nominal association of a low-frequency, missense RENBP variant was identified. Each minor allele of rs78377269 conferred a 2.21-fold (95% CI: 1.10, 4.42) increased odds of salt-sensitivity (P = 0.03). CONCLUSIONS: This study presents of the first evidence of a contribution of rare RAAS variants to BP salt-sensitivity. Clinical Trial RegistryTrial Number: NCT00721721. Twit Text FOAVip Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study ????Am J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=28199472 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28199472 #FOAvip English Wikipedia <ref>{{Cite pmid|28199472 }}</ref> Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone System Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study #MMPMID28199472 Kelly TN ; Li C ; Hixson JE ; Gu D ; Rao DC ; Huang J ; Rice TK ; Chen J ; Cao J ; Li J ; Anderson CE ; He J Am J Hypertens 2017[May]; 30 (5 ): 495-501 PMID28199472 show ga BACKGROUND: The role of rare variants in blood pressure (BP) salt-sensitivity is unknown. We conducted a resequencing study of the renin-angiotensin-aldosterone system (RAAS) to identify rare variants associated with BP salt-sensitivity among participants of the Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study. METHODS: The GenSalt study was conducted among 1,906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/day) followed by a 7-day high-sodium feeding study (307.8 mmol sodium/day). The 300 most salt-sensitive and 300 most salt-resistant GenSalt participants were selected for the resequencing study. Seven RAAS genes were resequenced using capillary-based sequencing methods. Rare variants were tested for association with BP salt-sensitivity using traditional burden tests. Single-marker analyses were employed to test associations of low-frequency and common variants. RESULTS: Aggregate rare variant analysis revealed an association of the RAAS pathway with BP salt-sensitivity. Carriers of rare RAAS variants had a 1.55-fold [95% confidence interval (CI): 1.15, 2.10] higher odds of salt-sensitivity compared to noncarriers (P = 0.004), a finding which was significant after Bonferroni correction. A nominal association of the APLN gene with salt-sensitivity was also identified, with rare APLN variants conferring a 2.22-fold (95% CI: 1.05, 6.58) higher odds of salt-sensitivity (P = 0.03). Single-marker analyses did not identify variant-BP salt-sensitivity associations after Bonferroni adjustment. A nominal association of a low-frequency, missense RENBP variant was identified. Each minor allele of rs78377269 conferred a 2.21-fold (95% CI: 1.10, 4.42) increased odds of salt-sensitivity (P = 0.03). CONCLUSIONS: This study presents of the first evidence of a contribution of rare RAAS variants to BP salt-sensitivity. Clinical Trial RegistryTrial Number: NCT00721721. |*Polymorphism, Single Nucleotide [MESH] |Adult [MESH] |Apelin [MESH] |Blood Pressure/*genetics [MESH] |Carbohydrate Epimerases/genetics [MESH] |Carrier Proteins/genetics [MESH] |Chi-Square Distribution [MESH] |China/epidemiology [MESH] |Diet, Sodium-Restricted [MESH] |Female [MESH] |Gene Frequency [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Hypertension/diagnosis/epidemiology/*genetics/physiopathology [MESH] |Intercellular Signaling Peptides and Proteins/genetics [MESH] |Linear Models [MESH] |Male [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Odds Ratio [MESH] |Phenotype [MESH] |Renin-Angiotensin System/*genetics [MESH] |Risk Assessment [MESH] |Risk Factors [MESH] |Sodium Chloride, Dietary/administration & dosage/*adverse effects [MESH]Resequencing Study Identifies Rare Renin-Angiotensin-Aldosterone Syste(epmc).pdf DeepDyve Pubget Overpricing