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10.7554/eLife.31919 http://scihub22266oqcxt.onion/10.7554/eLife.31919 C5860865!5860865!29557779     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2018 ; 7 (ä): ä Nephropedia Template TP {{tp|p=29557779|t=2018. Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir |pdf=|usr=}}{{29557779}} gab.com Text Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=29557779 #FOAvip Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing type I interferon production and boosting viral titers in humans. We find that both human and sylvatic (reservoir) dengue viruses universally cleave human STING, but not the STING of primates implicated as reservoir species. The special ability of dengue to cleave STING is thus specific to humans and a few closely related ape species. Conversion of residues 78/79 to the human-encoded ?RG? renders all primate (and mouse) STINGs sensitive to viral cleavage. Dengue viruses may have evolved to increase viral titers in the dense and vast human population, while maintaining decreased titers and pathogenicity in the more rare animals that serve as their sustaining reservoir in nature. Twit Text FOAVip Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=29557779 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29557779 #FOAvip English Wikipedia <ref>{{Cite pmid|29557779}}</ref> Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir #MMPMID29557779 Stabell AC; Meyerson NR; Gullberg RC; Gilchrist AR; Webb KJ; Old WM; Perera R; Sawyer SL eLife 2018[]; 7 (ä): ä PMID29557779show ga Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing type I interferon production and boosting viral titers in humans. We find that both human and sylvatic (reservoir) dengue viruses universally cleave human STING, but not the STING of primates implicated as reservoir species. The special ability of dengue to cleave STING is thus specific to humans and a few closely related ape species. Conversion of residues 78/79 to the human-encoded ?RG? renders all primate (and mouse) STINGs sensitive to viral cleavage. Dengue viruses may have evolved to increase viral titers in the dense and vast human population, while maintaining decreased titers and pathogenicity in the more rare animals that serve as their sustaining reservoir in nature. äDengue viruses cleave STING in humans but not in nonhuman primates, th(epmc).pdf DeepDyve Pubget Overpricing