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10.1016/j.celrep.2018.01.074 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.01.074 C5860817!5860817 !29466739     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29466739 &cmd=llinks): Failed to open stream: HTTP request failed! 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Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance |pdf=|usr=}}{{29466739 }} gab.com Text Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29466739 #FOAvip While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-term anti-miR-33 therapies and predisposition of miR-33(-/-) mice to obesity and metabolic dysfunction exemplify the possible pitfalls of miRNA-based therapies. Our work provides an in-depth characterization of miR-33(-/-) mice and explores the mechanisms by which loss of miR-33 promotes insulin resistance in key metabolic tissues. Contrary to previous reports, our data do not support a direct role for SREBP-1-mediated lipid synthesis in promoting these effects. Alternatively, in adipose tissue of miR-33(-/-) mice, we observe increased pre-adipocyte proliferation, enhanced lipid uptake, and impaired lipolysis. Moreover, we demonstrate that the driving force behind these abnormalities is increased food intake, which can be prevented by pair feeding with wild-type animals. Twit Text FOAVip Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29466739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29466739 #FOAvip English Wikipedia <ref>{{Cite pmid|29466739 }}</ref> Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance #MMPMID29466739 Price NL ; Singh AK ; Rotllan N ; Goedeke L ; Wing A ; Canfrán-Duque A ; Diaz-Ruiz A ; Araldi E ; Baldán Á ; Camporez JP ; Suárez Y ; Rodeheffer MS ; Shulman GI ; de Cabo R ; Fernández-Hernando C Cell Rep 2018[Feb]; 22 (8 ): 2133-2145 PMID29466739 show ga While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-term anti-miR-33 therapies and predisposition of miR-33(-/-) mice to obesity and metabolic dysfunction exemplify the possible pitfalls of miRNA-based therapies. Our work provides an in-depth characterization of miR-33(-/-) mice and explores the mechanisms by which loss of miR-33 promotes insulin resistance in key metabolic tissues. Contrary to previous reports, our data do not support a direct role for SREBP-1-mediated lipid synthesis in promoting these effects. Alternatively, in adipose tissue of miR-33(-/-) mice, we observe increased pre-adipocyte proliferation, enhanced lipid uptake, and impaired lipolysis. Moreover, we demonstrate that the driving force behind these abnormalities is increased food intake, which can be prevented by pair feeding with wild-type animals. |*Gene Deletion [MESH] |Adipose Tissue/metabolism/*pathology [MESH] |Adiposity [MESH] |Animals [MESH] |Cholesterol, HDL/blood/metabolism [MESH] |Cholesterol, LDL/blood [MESH] |Eating/*genetics [MESH] |Enzyme Activation [MESH] |Gene Expression Regulation [MESH] |Genetic Predisposition to Disease [MESH] |Germ Cells/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Insulin Resistance/*genetics [MESH] |Lipid Metabolism/genetics [MESH] |Liver/metabolism [MESH] |Mice, Inbred C57BL [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Models, Biological [MESH] |Obesity/blood/*genetics/pathology [MESH] |Protein Kinase C-epsilon/metabolism [MESH]Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tis(epmc).pdf DeepDyve Pubget Overpricing