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10.4161/auto.25803

http://scihub22266oqcxt.onion/10.4161/auto.25803
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C5860799!5860799!23934085
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suck abstract from ncbi


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pmid23934085      Autophagy 2013 ; 9 (10): 1621-3
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  • Histone post-translational modifications regulate autophagy flux and outcome #MMPMID23934085
  • Füllgrabe J; Klionsky DJ; Joseph B
  • Autophagy 2013[Oct]; 9 (10): 1621-3 PMID23934085show ga
  • Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily cytoprotective, autophagy can also contribute to cell death; it is thus important to understand what distinguishes the life or death decision in autophagic cells. Despite the fact that the execution of autophagy includes a unique set of cytoplasmic events, nuclear events, in particular transcriptional programs, have emerged as an important regulator of this process. In addition, a critical linkage was recently unveiled between specific histone posttranslational modifications and the transcriptional regulation of autophagy-related genes, which initiates a regulatory feedback loop, and serves as a key determinant of survival versus death responses upon autophagy induction.
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