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10.1093/bioinformatics/btw716 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btw716 C5860042!5860042!28011777     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioinformatics 2017 ; 33 (5): 754-6 Nephropedia Template TP {{tp|p=28011777|t=2017. Expanding the toolkit for membrane protein modeling in Rosetta |pdf=|usr=}}{{28011777}} gab.com Text Expanding the toolkit for membrane protein modeling in Rosetta JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=28011777 #FOAvip Motivation: A range of membrane protein modeling tools has been developed in the past 5?10 years, yet few of these tools are integrated and make use of existing functionality for soluble proteins. To extend existing methods in the Rosetta biomolecular modeling suite for membrane proteins, we recently implemented RosettaMP, a general framework for membrane protein modeling. While RosettaMP facilitates implementation of new methods, addressing real-world biological problems also requires a set of accessory tools that are used to carry out standard modeling tasks.Results: Here, we present six modeling tools, including de novo prediction of single trans-membrane helices, making mutations and refining the structure with different amounts of flexibility, transforming a protein into membrane coordinates and optimizing its embedding, computing a Rosetta energy score, and visualizing the protein in the membrane bilayer. We present these methods with complete protocol captures that allow non-expert modelers to carry out the computations.Availability and Implementation: The presented tools are part of the Rosetta software suite, available at www.rosettacommons.org.Contact:julia.koehler.leman@gmail.comSupplementary information:Supplementary data are available at Bioinformatics online. Twit Text FOAVip Expanding the toolkit for membrane protein modeling in Rosetta ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=28011777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28011777 #FOAvip English Wikipedia <ref>{{Cite pmid|28011777}}</ref> Expanding the toolkit for membrane protein modeling in Rosetta #MMPMID28011777 Koehler Leman J; Mueller BK; Gray JJ Bioinformatics 2017[Mar]; 33 (5): 754-6 PMID28011777show ga Motivation: A range of membrane protein modeling tools has been developed in the past 5?10 years, yet few of these tools are integrated and make use of existing functionality for soluble proteins. To extend existing methods in the Rosetta biomolecular modeling suite for membrane proteins, we recently implemented RosettaMP, a general framework for membrane protein modeling. While RosettaMP facilitates implementation of new methods, addressing real-world biological problems also requires a set of accessory tools that are used to carry out standard modeling tasks.Results: Here, we present six modeling tools, including de novo prediction of single trans-membrane helices, making mutations and refining the structure with different amounts of flexibility, transforming a protein into membrane coordinates and optimizing its embedding, computing a Rosetta energy score, and visualizing the protein in the membrane bilayer. We present these methods with complete protocol captures that allow non-expert modelers to carry out the computations.Availability and Implementation: The presented tools are part of the Rosetta software suite, available at www.rosettacommons.org.Contact:julia.koehler.leman@gmail.comSupplementary information:Supplementary data are available at Bioinformatics online. äExpanding the toolkit for membrane protein modeling in Rosetta (epmc).pdf DeepDyve Pubget Overpricing