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10.1016/j.cbpa.2013.04.009 http://scihub22266oqcxt.onion/10.1016/j.cbpa.2013.04.009 C5859939!5859939!23647985     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Chem+Biol 2013 ; 17 (3): 346-52 Nephropedia Template TP {{tp|p=23647985|t=2013. Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases |pdf=|usr=}}{{23647985}} gab.com Text Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases JO: Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23647985 #FOAvip Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostasis through translational attenuation of new protein synthesis and transcriptional remodeling of ER proteostasis pathways, providing a mechanism to adapt ER proteostasis in response to cellular stress. The capacity of the UPR to alter ER proteostasis suggests that exogenous manipulation of UPR signaling pathways offers therapeutic promise to alter the fate of pathologic proteins associated with human protein misfolding diseases. Here, we discuss the therapeutic potential of exogenous UPR activation to treat human disease and highlight specific small molecule approaches for regulating UPR signaling that could be beneficial to treat protein misfolding diseases. Twit Text FOAVip Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases ????Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=23647985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23647985 #FOAvip English Wikipedia <ref>{{Cite pmid|23647985}}</ref> Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases #MMPMID23647985 Ryno LM; Wiseman RL; Kelly JW Curr Opin Chem Biol 2013[Jun]; 17 (3): 346-52 PMID23647985show ga Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated by the accumulation of misfolded proteins within the ER lumen. Activation of the UPR alters ER proteostasis through translational attenuation of new protein synthesis and transcriptional remodeling of ER proteostasis pathways, providing a mechanism to adapt ER proteostasis in response to cellular stress. The capacity of the UPR to alter ER proteostasis suggests that exogenous manipulation of UPR signaling pathways offers therapeutic promise to alter the fate of pathologic proteins associated with human protein misfolding diseases. Here, we discuss the therapeutic potential of exogenous UPR activation to treat human disease and highlight specific small molecule approaches for regulating UPR signaling that could be beneficial to treat protein misfolding diseases. äTargeting unfolded protein response signaling pathways to ameliorate p(epmc).pdf DeepDyve Pubget Overpricing