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10.1186/s12915-018-0504-9

http://scihub22266oqcxt.onion/10.1186/s12915-018-0504-9
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C5859409!5859409!29554913
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suck abstract from ncbi


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pmid29554913      BMC+Biol 2018 ; 16 (ä): ä
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  • Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins #MMPMID29554913
  • Zhu Y; Zhang F; Huang Z
  • BMC Biol 2018[]; 16 (ä): ä PMID29554913show ga
  • A molecular arms race is progressively being unveiled between prokaryotes and viruses. Prokaryotes utilize CRISPR-mediated adaptive immune systems to kill the invading phages and mobile genetic elements, and in turn, the viruses evolve diverse anti-CRISPR proteins to fight back. The structures of several anti-CRISPR proteins have now been reported, and here we discuss their structural features, with a particular emphasis on topology, to discover their similarities and differences. We summarize the CRISPR-Cas inhibition mechanisms of these anti-CRISPR proteins in their structural context. Considering anti-CRISPRs in this way will provide important clues for studying their origin and evolution.
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