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10.1126/science.aan6836 http://scihub22266oqcxt.onion/10.1126/science.aan6836 C5858873!5858873!29097492     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 358 (6365): 929-32 Nephropedia Template TP {{tp|p=29097492|t=2017. Antibody-dependent enhancement of severe dengue disease in humans |pdf=|usr=}}{{29097492}} gab.com Text Antibody-dependent enhancement of severe dengue disease in humans JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=29097492 #FOAvip For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers. By contrast, we observe protection from all symptomatic dengue disease at high antibody titers. Thus, immune correlates of severe dengue must be evaluated separately from correlates of protection against symptomatic disease. These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern. Twit Text FOAVip Antibody-dependent enhancement of severe dengue disease in humans ????Science http://www.kidney.de/pget.php?&tw=1&pmid=29097492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29097492 #FOAvip English Wikipedia <ref>{{Cite pmid|29097492}}</ref> Antibody-dependent enhancement of severe dengue disease in humans #MMPMID29097492 Katzelnick LC; Gresh L; Halloran ME; Mercado JC; Kuan G; Gordon A; Balmaseda A; Harris E Science 2017[]; 358 (6365): 929-32 PMID29097492show ga For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers. By contrast, we observe protection from all symptomatic dengue disease at high antibody titers. Thus, immune correlates of severe dengue must be evaluated separately from correlates of protection against symptomatic disease. These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern. äAntibody-dependent enhancement of severe dengue disease in humans (epmc).pdf DeepDyve Pubget Overpricing