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10.1126/science.aah5651 http://scihub22266oqcxt.onion/10.1126/science.aah5651 C5858868!5858868!27738016     free     free     free       Science 2016 ; 354 (6313): ä Nephropedia Template TP {{tp|p=27738016|t=2016. RNA interference is essential for cellular quiescence |pdf=|usr=}}{{27738016}} gab.com Text RNA interference is essential for cellular quiescence JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27738016 #FOAvip Quiescent cells play a predominant role in most organisms. Here, we identify RNA interference (RNAi) as a major requirement for quiescence (G0) in Schizosaccharomyces pombe. RNAi mutants lose viability at G0-entry and are unable to maintain long-term quiescence. We obtained dcr1? G0 suppressors, which mapped to genes involved in chromosome segregation, RNA polymerase-associated factors, and heterochromatin formation. We propose a model in which RNAi promotes RNA polymerase release in cycling and quiescent cells: (i) RNA pol II release mediates heterochromatin formation at centromeres allowing proper chromosome segregation during mitotic growth and G0-entry, and (ii) RNA pol I release prevents heterochromatin formation at rDNA during quiescence maintenance. Our model may account for the co-dependency of RNAi and H3K9 methylation throughout eukaryotic evolution. Twit Text FOAVip RNA interference is essential for cellular quiescence ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27738016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27738016 #FOAvip English Wikipedia <ref>{{Cite pmid|27738016}}</ref> RNA interference is essential for cellular quiescence #MMPMID27738016 Roche B; Arcangioli B; Martienssen R Science 2016[Nov]; 354 (6313): ä PMID27738016show ga Quiescent cells play a predominant role in most organisms. Here, we identify RNA interference (RNAi) as a major requirement for quiescence (G0) in Schizosaccharomyces pombe. RNAi mutants lose viability at G0-entry and are unable to maintain long-term quiescence. We obtained dcr1? G0 suppressors, which mapped to genes involved in chromosome segregation, RNA polymerase-associated factors, and heterochromatin formation. We propose a model in which RNAi promotes RNA polymerase release in cycling and quiescent cells: (i) RNA pol II release mediates heterochromatin formation at centromeres allowing proper chromosome segregation during mitotic growth and G0-entry, and (ii) RNA pol I release prevents heterochromatin formation at rDNA during quiescence maintenance. Our model may account for the co-dependency of RNAi and H3K9 methylation throughout eukaryotic evolution. äRNA interference is essential for cellular quiescence (epmc).pdf DeepDyve Pubget Overpricing