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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 SAGE+Open+Med 2018 ; 6 (ä): ä Nephropedia Template TP
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Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy #MMPMID29568524
Fernandez-Moure J; Moore CA; Kim K; Karim A; Smith K; Barbosa Z; Van Eps J; Rameshwar P; Weiner B
SAGE Open Med 2018[]; 6 (ä): ä PMID29568524show ga
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. Literature has made substantial progress in understanding the biological basis of intervertebral disc, which is reviewed here. Current medical and surgical management strategies have shortcomings that do not lend promise to be effective solutions in the coming years. With advances in understanding the cell biology and characteristics of the intervertebral disc at the molecular and cellular level that have been made, alternative strategies for addressing disc pathology can be discovered. A brief overview of the anatomic, cellular, and molecular structure of the intervertebral disc is provided as well as cellular and molecular pathophysiology surrounding intervertebral disc degeneration. Potential therapeutic strategies involving stem cell, protein, and genetic therapy for intervertebral disc degeneration are further discussed.